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Introduction: Palliative care (PC) is essential in the treatment of patients with interstitial lung diseases (ILD). There is no data on the management of PC by pulmonologists in Argentina for ILD patients. This study aimed to describe the approach to PC in ILD patients in Argentina.
Methods: A 38-item survey was conducted among pulmonologists from the Argentine Association of Respiratory Medicine (N=1200). The survey was emailed twice in November and December 2023. It addressed medical training, healthcare organization, access and control of PC symptoms, and end-of-life care planning.
Results: A total of 101 pulmonologists responded to the survey. Among the respondents, 92.1% expressed interest in PC, and 45.5% had received theoretical or practical training. Additionally, 59.4% reported access to a hospital PC team, and 51.5% did not have a home PC team. Furthermore, 46.7% referred patients to the PC team, and 49.5% reached a consensus with their patients on the preferred place of death. Finally, 55.4% referred patients to PC in the final stage of the disease.
Discussion: Despite the majority of physicians recognizing the importance of PC, there are significant deficiencies in access to these services and in the knowledge about them. Furthermore, there is a lack of multidisciplinary collaboration. Addressing these gaps is crucial for improving the quality of life for ILD patients.
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Z Rheumatol
September 2025
Clinic of Internal Medicine III, Department of Oncology, Hematology, Cell and Immunotherapies, Clinical Immunology and Rheumatology, University Hospital Bonn, Venusberg Campus 1, 53127, Bonn, Germany.
Background: Interstitial lung diseases (ILD) represent an interdisciplinary clinical challenge and are not uncommonly associated with rheumatological diseases. Interstitial lung disease multidisciplinary meetings (ILD-MDM) provide a structured platform for interdisciplinary case discussions and decision making. Despite their great importance in patient care, data on the prevalence, structure and function of ILD-MDM in Germany are lacking.
View Article and Find Full Text PDFAnn Rheum Dis
September 2025
Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Department of Rheumatology, Oslo University Hospital, Oslo, Norway. Electronic address:
Background: Interstitial lung disease (ILD) is a frequent manifestation of connective tissue diseases (CTDs) and is associated with high morbidity and mortality. Clinical practice guidelines to standardise screening, diagnosis, treatment and follow-up for CTD-ILD are of high importance for optimised patient care.
Methods: A European Respiratory Society and European Alliance of Associations for Rheumatology task force committee, composed of pulmonologists, rheumatologists, pathologists, radiologists, methodologists and patient representatives, developed recommendations based on PICO (Patients, Intervention, Comparison, Outcomes) questions with grading of the evidence according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology and complementary narrative questions agreed on by both societies.
ESMO Open
September 2025
Sarah Cannon Research Institute United Kingdom, London, UK. Electronic address:
Background: Antibody-drug conjugates (ADCs) combine targeted monoclonal antibodies with cytotoxic payloads and are an emerging modality in systemic cancer therapy. Thirteen ADCs are Food and Drug Administration approved, with many more in development. However, design and use remain challenging, with issues including on/off-target toxicity, resistance from prior exposure to payload classes, and optimal target/payload selection.
View Article and Find Full Text PDFRheumatology (Oxford)
September 2025
Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy.
Objectives: To describe the prevalence of gastrointestinal (GI) symptoms in systemic sclerosis (SSc) and Very Early Diagnosis of SSc (VEDOSS), identify clinical and serological features associated with GI involvement, and explore a cranio-caudal pattern of symptom distribution, using data from the Italian SPRING-SIR registry.
Methods: This cross-sectional analysis included patients fulfilling 2013 ACR/EULAR SSc or VEDOSS criteria. GI involvement was defined as symptoms in at least one GI tract segment and categorized as upper and lower.
Rheumatology (Oxford)
September 2025
Department of Internal Medicine (IV), Division of Rheumatology, Osaka Medical and Pharmaceutical University, Osaka, Japan.
Objectives: This study aimed to establish a risk prediction model for the relapse of anti-synthetase syndrome-associated interstitial lung disease (ASyS-ILD).
Methods: Patients diagnosed with ASyS-ILD and treated with prednisolone and calcineurin inhibitors as remission induction therapy were enrolled in the Japanese multicentre MYKO cohort. We followed up on patients who experienced relapse of ASyS-ILD after remission induction therapy, and examined the risk factors for predicting relapse by comparing initial clinical and laboratory findings.