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Hypomagnesemia and Acute Cognitive Decline in Older Adults: An Evaluation of Clinical Practice and Cognitive Outcomes at a National Health Service (NHS) Trust in England.
Cureus
July 2025
General Medicine, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, GBR.
Introduction Magnesium is essential for regulating cardiovascular, neuromuscular, and respiratory functions. Hypomagnesemia in older adults is often overlooked and insufficiently managed. Inadequate monitoring and correction of hypomagnesemia may leave old and frail patients more vulnerable to acute cognitive decline, which in some cases can be preventable.
View Article and Find Full Text PDFRole of Serum Magnesium Deficiency in Insulin Resistance Among Overweight and Obese Children: A Meta-Analysis.
Cureus
August 2025
Pediatrics, The Children's Hospital, Lahore, PAK.
Magnesium is an essential micronutrient that plays a critical role in insulin signaling, glucose metabolism, and energy balance. With the growing global burden of childhood obesity and metabolic dysfunction, serum magnesium deficiency has emerged as a potential modifiable factor in the development of insulin resistance. This meta-analysis aimed to evaluate the association between serum magnesium levels and insulin resistance among overweight and obese children.
View Article and Find Full Text PDFTemporal Variation of Biochemical Markers and Adenoma Predictors in Normocalcemic Primary Hyperparathyroidism: A Multicenter Retrospective Analysis.
Clin Endocrinol (Oxf)
September 2025
Department of Endocrinology and Metabolism, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Objective: This study aimed to evaluate the diagnostic performance of biochemical markers in normocalcemic primary hyperparathyroidism (nPHPT), analyse their temporal variations, and assess their correlation with adenoma localisation and size.
Methods: In this multicenter retrospective study-the largest patient cohort reported in the literature to date (n = 474) we comprehensively profiled normocalcemic patients diagnosed with primary hyperparathyroidism nPHPT was diagnosed based on persistently elevated PTH levels with normal serum calcium after excluding secondary causes such as vitamin D deficiency, renal impairment, and other conditions. This retrospective multicenter study included a large cohort of patients whose biochemical markers-including serum calcium, phosphorus, magnesium, vitamin D, parathyroid hormone (PTH), and glomerular filtration rate (GFR)-were measured at three time points, using standardised laboratory protocols.
Serum magnesium and outcomes in heart failure with reduced ejection fraction: the GALACTIC-HF trial.
Eur Heart J
August 2025
British Heart Foundation Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
Background And Aims: The frequency and prognostic significance of abnormalities in serum magnesium concentrations have not been described in a contemporary HF population. The authors evaluated the prognostic significance of magnesium concentrations in patients with HFrEF enrolled in GALACTIC-HF trial.
Methods: GALACTIC-HF was a randomized, double-blind, multicentre, event-driven trial that investigated the efficacy and safety of omecamtiv mecarbil compared to placebo in HF patients with LVEF ≤35%.