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http://dx.doi.org/10.1038/s41557-024-01679-7 | DOI Listing |
Educ Prim Care
September 2025
Department of Family Medicine, Shifa College of Medicine, Shifa Tameer e Millat University, Islamabad, Pakistan.
Human touch holds an important role in field of medicine promoting empathy, trust and connection between doctors, patients and students. This teaching exchange digs into the complex dynamics of 'Human Touch' in medical education and clinical practice exploring its positive, negative and ambiguous aspects. A comforting touch can convey compassion, enhance patient care, alleviate pain and can build trust.
View Article and Find Full Text PDFJ Prof Nurs
September 2025
Wellstar School of Nursing, Kennesaw State University, 520 Parliament Garden Way NW, MDC 4102, Kennesaw, GA 30144, USA.
There is an urgent call to transform nursing education in response to evolving changes in healthcare. It is critical that nursing graduates are prepared to thrive and deliver care in complex environments to increasingly diverse populations. This article describes a nursing school's approach to achieve these goals and presents details of work completed during the early phases of curriculum revision to integrate the American Association of Colleges of Nursing's (AACN's) 2021 publication, The Essentials: Core Competencies for Professional Nursing Education, into the baccalaureate programs.
View Article and Find Full Text PDFJ R Coll Physicians Edinb
September 2025
Department of Diabetes and Endocrinology, University Hospitals of North Midlands NHS Trust, Stoke-on-Trent, UK.
The Royal College of Physicians flagship chief registrar programme, an initiative launched nearly a decade ago was an innovative leadership and management programme for medical registrars which has now been rolled out to other specialties as well. The role has evolved over time and explores the broader aspects of the ways of workings in the UK National Health Service, the progression and impact for individuals, teams and organisations across the wider health economy both from the perspective of acute care as well as treating long-term conditions. A personal reflection on connecting the experiential learning attained from being a chief registrar and transitioning through this unique and distinctive programme towards embedding into the Consultant Physician job that encompasses broadening horizons into non-clinical managerial domains such as Clinical Lead from a service line perspective as well as academic Co-lead to widen the landscape of undergraduate medical school placements is illustrated in this article.
View Article and Find Full Text PDFTrends Mol Med
September 2025
Institute of Pharmacology and Toxicology, University of Würzburg, 97078 Würzburg, Germany; Leibniz-Institut für Analytische Wissenschaften (ISAS) e.V., 44139 Dortmund, Germany. Electronic address:
Dysregulation of the RAF-MEK-ERK1/2 pathway is involved in the pathoetiology of many diseases. Its central role in cancer has led to the development of drugs targeting upstream receptors, RAS, and kinases in the extracellular signal-regulated kinase 1 (ERK1) and 2 (ERK2) signaling cascade. The use of these drugs in cancer therapy - together with ongoing monitoring of their effectiveness, evolving side-effects, and resistance mechanisms - has expanded our knowledge of both the physiological and pathological functions of ERK1/2 and could thus provide potential alternative therapeutic strategies.
View Article and Find Full Text PDFJ Invest Dermatol
September 2025
LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, DK. Electronic address:
Liquid chromatography-mass spectrometry (LC-MS) is an evolving tool for comprehensive proteomic analyses across tissues. Despite the widespread use of LC-MS in dermatology, full-thickness human skin remains challenging to analyse. The skin extracellular matrix (ECM) presents two major obstacles: the extensive crosslinking complicates protein extraction and the high abundance of ECM proteins can mask lower-abundance proteins, reducing identification numbers.
View Article and Find Full Text PDF