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Anterior vertebral tethering (AVT) is a non-invasive spine surgery technique, treating severe spine deformations and preserving lower back mobility. However, patient positioning and surgical strategies greatly influences postoperative results. Predicting the upright geometry from pediatric spines is needed to optimize patient positioning in the operating room (OR) and improve surgical outcomes, but remains a complex task due to immature bone properties. We propose a framework used in the OR predicting the upright spine geometry at the first visit following surgery in idiopathic scoliosis patients. The approach first creates a 3D model of the spine while the patient is on the operating table. For this, multiview Transformers that combine images from different viewpoints are used to generate the intraoperative pose. The postoperative upright shape is then predicted on-the-fly using implicit neural fields, which are trained from geometries at different time points and conditioned with surgical parameters. A Signed Distance Function for shape constellations is used to handle the variability in spine appearance, capturing a disentangled latent domain of the articulation vectors, with separate encoding vectors representing both articulation and shape parameters. A regularization criterion based on a pre-trained group-wise trajectory of spine transformations generates complete spine models. A training set of 652 patients with 3D models was used to train the model, tested on a distinct cohort of 83 surgical patients. The framework based on neural kernels predicted upright 3D geometries with a mean 3D error of 1.3±0.5mm in landmarks points, and IoU of 95.9% in vertebral shapes when compared to actual postop models, falling within the acceptable margins of error below 2 mm.
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http://dx.doi.org/10.1016/j.media.2024.103400 | DOI Listing |
Neurosurg Rev
September 2025
Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Purpose: To share our clinical experience with conservative management of isolated spinal arterial aneurysms (ISAs) and to identify clinical scenarios where conservative management may be appropriate, in the context of a literature review.
Methods: We performed a retrospective review of spinal angiograms from two German neuroradiology centers and conducted a systematic literature review of reported ISA cases. We analyzed demographics, clinical presentation, imaging findings, treatments, and outcomes.
J Cell Biol
November 2025
Life Sciences Institute, University of Michigan, Ann Arbor, MI, USA.
Two major protein recycling pathways have emerged as key regulators of enduring forms of synaptic plasticity, such as long-term potentiation (LTP), yet how these pathways are recruited during plasticity is unknown. Phosphatidylinositol-3-phosphate (PI(3)P) is a key regulator of endosomal trafficking and alterations in this lipid have been linked to neurodegeneration. Here, using primary hippocampal neurons, we demonstrate dynamic PI(3)P synthesis during chemical induction of LTP (cLTP), which drives coordinate recruitment of the SNX17-Retriever and SNX27-Retromer pathways to endosomes and synaptic sites.
View Article and Find Full Text PDFJ Int Med Res
September 2025
Department of Orthopedics and Traumatology, Health Sciences University Fatih Sultan Mehmet Training and Research Hospital, Turkey.
ObjectiveTo determine the effectiveness of bilateral decompression combined with a unilateral transforaminal lumbar interbody fusion approach in centralizing a lordotic cage and preventing contralateral radiculopathy by ensuring equal foraminal elevation.MethodsThis is a retrospective cohort study based on clinical records and radiological data. Eighty-seven patients diagnosed with lumbar spinal stenosis at L3-S1 levels underwent bilateral decompression and transforaminal lumbar interbody fusion between 2017 and 2022.
View Article and Find Full Text PDFClin Spine Surg
September 2025
Department of Orthopaedic Surgery, Spine Service, Hospital for Special Surgery, New York City, New York.
Study Design: Narrative review.
Objective: Summarize current classification systems, preoperative considerations, surgical approaches, and outcomes in patients with cervical deformity.
Summary Of Background Data: Cervical deformity (CD) is a complex pathology with varying presentations.
Clin Spine Surg
September 2025
Department of Neurosurgery, Neurosurgery, The Walton Centre NHS Foundation Trust, Lower Lane.
Study Design: Retrospective cohort study.
Objective: To characterise patients admitted to a UK tertiary centre with OPLL over a 10-year period.
Summary Of Background Data: OPLL is a progressive degenerative condition that can lead to myelopathy.