Publications by authors named "Garrett D Chavis"
Two major protein recycling pathways have emerged as key regulators of enduring forms of synaptic plasticity, such as long-term potentiation (LTP), yet how these pathways are recruited during plasticity is unknown. Phosphatidylinositol-3-phosphate (PI(3)P) is a key regulator of endosomal trafficking and alterations in this lipid have been linked to neurodegeneration. Here, using primary hippocampal neurons, we demonstrate dynamic PI(3)P synthesis during chemical induction of LTP (cLTP), which drives coordinate recruitment of the SNX17-Retriever and SNX27-Retromer pathways to endosomes and synaptic sites.
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- The trafficking of cell-surface proteins from endosomes to the plasma membrane is crucial for regulating synaptic function, with two main pathways identified: SNX27-Retromer-WASH and SNX17-Retriever-CCC-WASH.
- This study reveals that the SNX17 pathway is essential for maintaining excitatory synapses and supporting structural plasticity in neurons, particularly during chemical long-term potentiation (cLTP).
- SNX17's function at synapses is influenced by NMDAR activation and CaMKII signaling, highlighting its role in regulating β1-integrin levels and providing critical insight into synaptic maintenance and plasticity mechanisms.