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By delving into the applications, methodologies, and case studies of multi-dimensional crystallography, whereby time and temperature are varied in the context of allostery, this review aims to elucidate the intricate interplay between structure, dynamics, and function in allosteric proteins. As the field of structural biology continues to advance, integrating multi-dimensional approaches promises to unlock new frontiers in our quest to decipher the molecular mechanisms governing life.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604904 | PMC |
http://dx.doi.org/10.1007/s12551-024-01224-3 | DOI Listing |
Nature
February 2025
Department of Chemistry and Biochemistry and California Nanosystems Institute, University of California, Los Angeles, Los Angeles, CA, USA.
The construction of superlattices with a spatial modulation of chemical compositions allows for the creation of artificial materials with tailorable periodic potential landscapes and tunable electronic and optical properties. Conventional semiconductor superlattices with designable potential modulation in one dimension has enabled high-electron-mobility transistors and quantum-cascade lasers. More recently, a diverse set of superlattices has been constructed through self-assembly or guided assembly of multiscale building units, including zero-dimensional nanoclusters and nanoparticles, one-dimensional nanorods and nanowires, two-dimensional nanolayers and nanosheets, and hybrid two-dimensional molecular assemblies.
View Article and Find Full Text PDFBiophys Rev
October 2024
Institute for Nanostructure and Solid-State Physics, University of Hamburg, Hamburg, Germany.
Methods
October 2024
UofL Health Brown Cancer Center, University of Louisville, Louisville, KY, United States. Electronic address:
Guanine-rich nucleic acids can form intramolecularly folded four-stranded structures known as G-quadruplexes (G4s). Traditionally, G4 research has focused on short, highly modified DNA or RNA sequences that form well-defined homogeneous compact structures. However, the existence of longer sequences with multiple G4 repeats, from proto-oncogene promoters to telomeres, suggests the potential for more complex higher-order structures with multiple G4 units that might offer selective drug-targeting sites for therapeutic development.
View Article and Find Full Text PDFJ Muscle Res Cell Motil
December 2023
Department of Biology, University of Konstanz, 78457, Konstanz, Germany.
The thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important scaffolding properties that support thick filament assembly. It also has a demonstrated link to human disease. Despite its functional significance, it remains a largely uncharacterized part of the titin protein.
View Article and Find Full Text PDFSci Rep
January 2023
Department of Basic Sciences, Preparatory Year Deanship, King Faisal University, Al-Ahsa, 31982, Saudi Arabia.
Novel molybdenum (Mo)-doped nickel oxide (NiO) Nanoparticles (NPs) were synthesized by using a simple sonochemical methodology and the synthesized NPs were investigated for antioxidant, and antibacterial applications. The X-ray diffraction (XRD) analysis revealed that the crystal systems of rhombohedral (21.34 nm) and monoclinic (17.
View Article and Find Full Text PDF