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Objective: To evaluate the relationship between center volume and inpatient mortality after inter-hospital transfer among patients undergoing pediatric cardiac surgery using contemporary real-world data.
Methods: The Kids' Inpatient Database (KID) was queried for cardiopulmonary bypass (CPB) cases (CPB) for years 2016 and 2019. Hospitals were divided into three groups based on terciles of volume: "low": ≤103 cases/year, "mid":104-194 cases/year, and "high": >194 cases/year. Multilevel regression models were created to evaluate the association of volume and inpatient mortality for transferred patients for the entire cohort as well as high-complexity cases. (Risk Stratification for Congenital Heart Surgery (RACHS-2) categories 3,4 and 5).
Results: Of 25,749 patients undergoing cases on CPB, 3,511 (13.6%) were preoperative inpatient transfers between hospitals. Compared to direct admissions, unadjusted mortality for patients who were transferred was higher in all groups: 1.7% vs. 5.6% (low-volume), 1.1% vs. 4.6% (mid-volume) and 1.1% vs. 4.9% (high-volume). Compared to low-volume hospitals, inpatient mortality for patients admitted on transfer was not significantly different in mid-volume (OR = 0.85, 95% CI 0.54-1.34, p = 0.483) and high-volume centers (OR = 0.7, 95% CI 0.45-1.12, p = 0.127) for the entire cohort. There was no significant difference in risk-adjusted inpatient mortality for high-complexity cases performed at mid-volume (OR 1.06, p = 0.845, 95% CI (0.62-1.85)) or high-volume hospitals (OR 0.82, p = 0.482, 95% CI (0.48-1.45)).
Conclusion: Annual CPB case volume may not accurately predict risk-adjusted inpatient mortality for children transferred for heart surgery. Annual case volume alone should not dictate transfer practices in pediatric heart surgery.
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http://dx.doi.org/10.21203/rs.3.rs-5356715/v1 | DOI Listing |
Crit Care Explor
September 2025
Division of Tropical Medicine and Infectious Diseases, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Importance: Sepsis remains a leading cause of death in infectious cases. The heterogeneity of immune responses is a major challenge in the management and prognostication of patients with sepsis. Identifying distinct immune response subphenotypes using parsimonious classifiers may improve outcome prediction, particularly in resource-limited settings.
View Article and Find Full Text PDFJ Palliat Care
September 2025
Department of Healthcare Administration and Policy, School of Public Health, University of Nevada, Las Vegas, NV, USA.
ObjectivesRecently, atrial fibrillation (AF) has contributed to an increase in cardiovascular deaths in the U.S. Palliative care (PC) and atrial ablation (AA) procedure can elevate quality of life of high-risk AF patients, who are associated with multiple comorbidities.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
September 2025
Institute for Community Medicine, Section Epidemiology of Health Care and Community Health, University Medicine Greifswald, Greifswald, Germany.
Purpose: The German sector-based healthcare system poses a major challenge to continuous patient monitoring and long-term follow-up, both essential for generating high-quality, longitudinal real-world data. The national Network for Genomic Medicine (nNGM) bridges the inpatient and outpatient care sectors to provide comprehensive molecular diagnostics and personalized treatment for non-small cell lung cancer (NSCLC) patients in Germany. Building on the established nNGM infrastructure, the DigiNet study aims to evaluate the impact of digitally integrated, personalized care on overall survival (OS) and the optimization of treatment pathways, compared to routine care.
View Article and Find Full Text PDFJTCVS Open
August 2025
Department of Cardiac Surgery, University of Michigan Medical School, Ann Arbor, Mich.
Background: Regular imaging surveillance is guideline-recommended for the management of thoracic aortic aneurysm (TAA) but has not been well described in clinical practice. Here we evaluated the frequency of imaging procedures and associated outcomes, procedures, and healthcare costs in patients with TAA.
Methods: A retrospective cohort study of inpatient and professional claims for 28,459 Medicare beneficiaries age ≥65 years with a diagnosis of TAA between 2017 and 2019 was performed.
Crit Care Med
July 2025
Division of Critical Care, Department of Medicine, The Queen's Medical Center, Honolulu, HI.
Objectives: To evaluate the relationship between the duration of pre-extracorporeal membrane oxygenation (ECMO) mechanical ventilation and mortality in acute respiratory distress syndrome (ARDS) patients undergoing venovenous ECMO.
Design: Retrospective cross-sectional study using the National Inpatient Sample database.
Setting: National Inpatient Sample database from January 2019 to December 2022.