Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Understanding the regulation of somatic stem cells, both during homeostasis and in response to environmental challenges like injury, infection, chemical exposure, and nutritional changes, is critical because their dysregulation can result in tissue degeneration or tumorigenesis. The use of models such as the and mammalian adult intestines offers valuable insights into tissue homeostasis and regeneration, advancing our knowledge of stem cell biology and cancer development. This review highlights significant findings from recent studies, unveiling the molecular mechanisms that govern self-renewal, proliferation, differentiation, and regeneration of intestinal stem cells (ISCs). These insights not only enhance our understanding of normal tissue maintenance but also provide critical perspectives on how ISC dysfunction can lead to pathological conditions such as colorectal cancer (CRC).
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11592481 | PMC |
| http://dx.doi.org/10.3390/cells13221856 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeting Intestinal Permeability for Graft-versus-Host Disease Treatment: A Therapeutic Perspective with Defibrotide.
J Exp Pharmacol
September 2025
Department of Translational Medicine, University of Ferrara, Ferrara, Italy.
Purpose: Acute graft-versus-host disease (aGVHD) is a significant cause of death in recipients of allogeneic hematopoietic stem cell transplantation. In this type of graft, the intestine is particularly affected, with the loss of intestinal barrier integrity playing a key role in its onset. In this scenario, the aim of the present research was to evaluate defibrotide, a heparin-like compound, marked for severe veno-occlusive disease, as an innovative therapeutic approach for restoring intestinal barrier integrity using an in vitro model and analyzing aGVHD patients' sera and clinical data.
View Article and Find Full Text PDFIntestinal epithelial Ceacam1 deficiency prevents steroid-refractory acute gut graft-versus-host disease.
JCI Insight
September 2025
Arthur D. Riggs Diabetes and Metabolism Research Institute, The Beckman Research Institute, and.
Steroid-refractory gut acute graft-versus-host disease (SR-Gut-aGVHD) is the major cause of nonrelapse death after allogeneic hematopoietic cell transplantation. High numbers of donor-type IL-22+ T cells, IL-22-dependent dysbiosis, and loss of antiinflammatory CX3CR1hi mononuclear phagocytes (MNPs) play critical roles in SR-Gut-aGVHD pathogenesis. CEACAM1 on intestinal epithelial cells (IECs) is proposed to regulate bacterial translocation and subsequent immune responses in the intestine.
View Article and Find Full Text PDFAnti-obesity effects of water-dispersible turmeric extract via gut barrier and metabolite modulation in high-fat diet-fed mice.
Food Res Int
November 2025
Food Functionality Research Division, Korea Food Research Institute, Jeollabuk-do 55365, Republic of Korea; Department of Food Biotechnology, Korea National University of Science and Technology, Daejeon 34113, Republic of Korea. Electronic address:
Turmeric (Curcuma longa) exhibits anti-obesity properties, yet its low water solubility limits bioavailability. In this study, a water-dispersible turmeric rhizome extract (WDTE) was developed using nano-dispersion technology with maltodextrin as a wall material and characterized by UPLC-QTOF-MS, dynamic light scattering, and zeta potential analysis. The WDTE contained 10 identified metabolites, including five diarylheptanoids such as curcumin, demethoxycurcumin, and bisdemethoxycurcumin, with curcumin quantified at 7.
View Article and Find Full Text PDF[Monomorphic epitheliotropic intestinal T-cell lymphoma: a clinicopathological and genetic mutation characteristics analysis of forty-two cases].
Zhonghua Bing Li Xue Za Zhi
September 2025
Department of Pathology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
To investigate the clinicopathological and genetic characteristics of monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL). The forty-two MEITL cases diagnosed in the Department of Pathology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China from 2016 to 2022 was retrospectively analyzed. Clinical data were collected, and follow-up was performed.
View Article and Find Full Text PDFUltrasonic-assisted three-phase partitioning with deep eutectic solvents for extraction of Nostoc commune Vauch polysaccharides and their anti-ulcerative colitis activity.
Int J Biol Macromol
September 2025
The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, School of Pharmacy, Guangdong Medical University, Dongguan, 523808, China.
This study explores the extraction of polysaccharides from Nostoc commune Vauch. using ultrasonic-assisted three-phase partitioning with deep eutectic solvents (UA-TPP-DES). Response surface methodology was used to determine the optimized UA-TPP-DES conditions as follows: a 1: 2 M ratio of lauric acid to terpineol, 30 min of ultrasonication at 60 °C with 100 W power, 20 % moisture content, 20 % w/w (NH)SO concentration, and a 2: 1 top-to-bottom phase volume ratio.
View Article and Find Full Text PDF