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Article Abstract
Introduction: The geroscience hypothesis proposes systemic biological aging is a root cause of cognitive decline.
Methods: We analyzed Framingham Heart Study Offspring Cohort data ( = 2296; 46% male; baseline age = 62, SD = 9, range = 25-101 y). We measured cognitive decline across two decades of neuropsychological-testing follow-up. We measured pace of aging using the DunedinPACE epigenetic clock. Analysis tested if participants with faster DunedinPACE values experienced more rapid cognitive decline compared with those with slower DunedinPACE values.
Results: Participants with faster DunedinPACE had poorer cognitive functioning at baseline and experienced more rapid cognitive decline over follow-up. Results were robust to confounders and consistent across population strata. Findings were similar for the PhenoAge and GrimAge epigenetic clocks.
Discussion: Faster pace of aging is a risk factor for preclinical cognitive decline. Metrics of biological aging may inform risk stratification in clinical trials and prognosis in patient care.
Highlights: Faster DunedinPACE is associated with preclinical cognitive aging.Higher baseline cognition was protective of DunedinPACE-associated cognitive decline.The DunedinPACE association with cognitive decline explained a fourth of dementia risk.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585167 | PMC |
| http://dx.doi.org/10.1002/dad2.70038 | DOI Listing |
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