Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: A new dual-chamber leadless pacemaker (DR-LP) system, composed of 2 implantable devices in the right ventricle and right atrium, uses a less common temperature-based rate-response sensor. There is a need to understand the effectiveness of the rate response during exercise in both the ventricular (VR-LP) and atrial (AR-LP) devices.
Objective: We sought to determine whether temperature-based rate-responsive pacing is proportional to metabolic workload during an exercise test in a leadless pacemaker system.
Methods: After 6 weeks of implantation, we administered a treadmill exercise protocol to eligible participants concurrently enrolled in the LEADLESS II-Phase 2 and Aveir DR i2i studies. Programmed settings were optimized after a prior 6-minute walk test. We evaluated the ventricular and atrial rate-response sensors in participants implanted with the VR-LP and DR-LP system, respectively. For each device, the normalized slopes of sensor-indicated rate vs metabolic workload were aggregated across all analyzable patients. If the mean slope's 95% confidence interval (CI) fell within the prespecified 0.65 and 1.35 acceptance range, the rate response was considered proportional to metabolic demand.
Results: Seventeen participants had a mean ventricular rate-response slope of 0.93 ± 0.29 (CI, 0.78-1.08), which fell within the acceptance criteria (P = .001). Twenty participants had a mean atrial rate-response slope of 0.91 ± 0.28 (CI, 0.78-1.05), also falling within the prespecified criteria (P < .001).
Conclusion: The temperature-based sensor in a dual-chamber leadless pacemaker system was shown to be effective at modulating pacing rate in response to increased metabolic demand for right ventricular and atrial devices.
Gov Identifier: NCT04559945 (LEADLESS II-Phase 2 study) and NCT05252702 (Aveir DR i2i study).
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.hrthm.2024.11.032 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Comparative effectiveness and safety of second-line therapies and dosing regimens for advanced hepatocellular carcinoma: a network meta-analysis.
Eur J Gastroenterol Hepatol
September 2025
Department of General Medicine, Affiliated Anqing First People's Hospital of Anhui Medical University, Anqing, Anhui, China.
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-associated death globally. Second-line therapies are crucial for improving survival and quality of life among individuals suffering from advanced HCC who have not responded to first-line therapies. This study sought to evaluate the safety and efficacy of different second-line therapies for advanced HCC by network meta-analysis.
View Article and Find Full Text PDFMarburg Virus Disease in Rwanda, 2024 - Public Health and Clinical Responses.
N Engl J Med
September 2025
Rwanda Biomedical Center, Kigali.
Background: On September 27, 2024, Rwanda reported an outbreak of Marburg virus disease (MVD), after a cluster of cases of viral hemorrhagic fever was detected at two urban hospitals.
Methods: We report key aspects of the epidemiology, clinical manifestations, and treatment of MVD during this outbreak, as well as the overall response to the outbreak. We performed a retrospective epidemiologic and clinical analysis of data compiled across all pillars of the outbreak response and a case-series analysis to characterize clinical features, disease progression, and outcomes among patients who received supportive care and investigational therapeutic agents.
Dietary nitrate supplementation suppresses sympathetic neural responses to mechanoreflex activation during static handgrip exercise in postmenopausal women.
J Appl Physiol (1985)
September 2025
Women's Heart Health Laboratory, Institute for Exercise and Environmental Medicine at Texas Health Presbyterian Hospital Dallas, TX, USA.
We investigated the impact of short-term dietary nitrate supplementation on sympathetic neural responses to isometric exercise in postmenopausal women. Ten healthy women aged 64±2 (SD) years participated in this randomized, placebo-controlled, double-blind, crossover study. All participants underwent two-week beetroot juice (BRJ: 800 mg nitrate/day) and placebo (nitrate-depleted BRJ) interventions with ≥14 days of wash-out.
View Article and Find Full Text PDFRobotic reading companions can mitigate oral reading anxiety in children.
Sci Robot
September 2025
University of Chicago, Chicago, IL 60637, USA.
Reading fluency is a vital building block for developing literacy, yet the best way to practice fluency-reading aloud-can cause anxiety severe enough to inhibit literacy development in ways that can have an adverse effect on students through adulthood. One promising intervention to mitigate oral reading anxiety is to have children read aloud to a robot. Although observations in prior work have suggested that people likely feel more comfortable in the presence of a robot instead of a human, few studies have empirically demonstrated that people feel less anxious performing in front of a robot compared with a human or used objective physiological indicators to identify decreased anxiety.
View Article and Find Full Text PDFEffects of sex and heating rate on skin blood flow oscillations during local heating in young adults.
Am J Physiol Regul Integr Comp Physiol
September 2025
Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
to explore sex and heating rate effects on frequency-domain indicators of the mechanisms modulating cutaneous vasodilation during local heating. In thirty young adults (21±3 years, 15 females), wavelet analysis of skin blood flux was assessed from laser-Doppler flux signals at the chest, abdomen, arm, forearm, thigh, and calf during rapid (33-42°C; 1°C·20 s) and gradual (33-42°C; 1°C·5 min) local skin heating. A wavelet transform using a Morlet mother wavelet was computed over the entire signal for each heating protocol (minimum 90 minutes) and 5-min time windows were subsequently isolated to determine responses during baseline and the 42°C heating plateau.
View Article and Find Full Text PDF