98%
921
2 minutes
20
Expert participation and collaboration are an efficient, transparent, credible and innovative way to implement open scientific data management, evaluation and analytical mining. An unprecedented surge in openly accessible earth surface system (ESS) data across web platforms has emerged. This data is characterized by dispersion, multi-sourcing, heterogeneity, and multi-modality, and predominantly manifests through thematic sharing websites, data services, metadata, and journal publications, particularly data papers. Addressing the pressing need to swiftly evaluate the sharing degree of these openly shared ESS data sets constitutes a new frontier in this domain. Current frameworks and tools designed for open scientific data sharing lack direct applicability to the intricacies of earth surface systems, thereby impeding users' access to data of high sharing degree. This study introduces an ESS-oriented evaluation tool tailored to assess the sharing degree of open ESS data. Central to this tool are the components of an evaluation metric system and an evaluation model. Leveraging the principles of FAIR (Findable, Accessible, Interoperable, and Reusable), a comprehensive sharing degree assessment index comprising 19 secondary metrics categorized under 5 primary metrics is formulated. Furthermore, a novel evaluation model for quantifying the sharing degree of open scientific data is proposed, integrating hierarchical analysis and the entropy method. This integration effectively captures the nuanced uncertainties and variability inherent in the data, enhancing the accuracy and reliability of evaluation outcomes. The resulting software tool facilitates rapid and quantitative assessment of open scientific data sharing degree within the ESS domain, thereby enabling the recommendation of highly-shared datasets to researchers and modelers alike.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.jenvman.2024.123432 | DOI Listing |
Diabetologia
September 2025
Walther Straub Institute of Pharmacology and Toxicology, LMU Munich, Munich, Germany.
Aims/hypothesis: Unimolecular peptides targeting the receptors for glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP) and glucagon (GCG) have been shown to improve glycaemic management in both mice and humans. Yet the identity of the downstream signalling events mediated by these peptides remain to be elucidated. Here, we aimed to assess the mechanisms by which a validated peptide triagonist for GLP-1/GIP/GCG receptors (IUB447) stimulates insulin secretion in murine pancreatic islets.
View Article and Find Full Text PDFAPMIS
September 2025
Laboratory of Parasitology, Department of Bacteria, Parasites and Fungi, Infectious Disease Preparedness, Statens Serum Institut, Copenhagen, Denmark.
Clinical microbiology involves the detection and differentiation of primarily bacteria, viruses, parasites and fungi in patients with infections. Billions of people may be colonised by one or more species of common luminal intestinal parasitic protists (CLIPPs) that are often detected in clinical microbiology laboratories; still, our knowledge on these organisms' impact on global health is very limited. The genera Blastocystis, Dientamoeba, Entamoeba, Endolimax and Iodamoeba comprise CLIPPs species, the life cycles of which, as opposed to single-celled pathogenic intestinal parasites (e.
View Article and Find Full Text PDFSoc Sci Med
September 2025
Department of Child Health and Development, Norwegian Institute of Public Health, Oslo, Norway.
Background: An upward trend in self-reported mental distress among adolescents has been documented in Norway and several other countries, yet the causes remain unclear. This study aims to identify potential explanations for this trend by testing hypothesized factors using repeated cross-sectional data.
Methods: We analyzed responses from 979,043 Norwegian adolescents, collected across 1417 municipality level surveys between 2011 and 2024.
Br J Cancer
September 2025
State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Key Laboratory of Radiation Damage and Countermeasures of Jiangsu Provincial Universities and Col
Background: In recent years, there has been a steady increase in professionals engaged in radioactive work. The biological impacts of long-term exposure to low dose-rate radiation remain elusive, as there is a dearth of systematic research in this field.
Methods: BEAS-2B cells were used to establish a cell model with continuous passaging after radiation exposure, which was subsequently subjected to in vivo tumorigenesis assays and in vitro malignant phenotype experiments.
Ageing Res Rev
September 2025
Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang, 110122, China; Laboratory of Naturel Medicine for drug discovery, School of Pharmacy, China Medical University, Shenyang, 110122, China. Electronic address:
Calcium (Ca)/calmodulin (CaM)-dependent protein kinase II (CaMKII) is an emerging drug target for age-related diseases. It is a multifunctional kinase with complex activation modes, numerous isoforms, broad tissue distribution, and a dual role in health and disease. In particular, its isoforms share a high degree of conservation within the catalytic and regulatory domains, with only minor differences confined to the linker region.
View Article and Find Full Text PDF