An open-label pilot study of non-invasive cervical vagus nerve stimulation in essential tremor.

Brain Stimul

Department of Medicine and Surgery, Unit of Neurology, Neurophysiology, Neurobiology and Psychiatry, Università Campus Bio-Medico di Roma, Italy; Fondazione Policlinico Universitario Campus Bio-Medico, Viale Alvaro del Portillo 200, 00128, Rome, Italy.

Published: November 2024


Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.brs.2024.11.008DOI Listing

Publication Analysis

Top Keywords

open-label pilot
4
pilot study
4
study non-invasive
4
non-invasive cervical
4
cervical vagus
4
vagus nerve
4
nerve stimulation
4
stimulation essential
4
essential tremor
4
open-label
1

Similar Publications

Background: Immunotherapy is a mainstay in the treatment of patients with advanced melanoma. Yet, resistance mechanisms exist, and tumour-associated macrophages (TAMs), particularly the M2-like phenotype, are associated with poorer outcomes, with CD206 serving as their specific marker. We present the first human SPECT/CT study to visualize CD206 + TAMs in patients undergoing immunotherapy and compare the findings to clinical outcomes (NCT04663126).

View Article and Find Full Text PDF

Background: Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia primarily affecting Black women. To date, there are no standardized treatment regimens or approved medications for the treatment of CCCA. This single-center, open-label, clinical study investigated the efficacy of apremilast in the treatment of mild to moderate vertex-predominant CCCA.

View Article and Find Full Text PDF

Postpartum hemorrhage (PPH) affects up to 44% of women with von Willebrand disease (VWD) despite recombinant VWF (rVWF) treatment. As tranexamic acid (TXA) reduced PPH-related deaths in the WOMAN trial, we assessed whether TXA combined with rVWF versus rVWF alone prevents PPH in VWD. VWD-Woman, a phase 3, open-label, randomized pilot trial, enrolled pregnant women ≥18 years with VWD (VWF:RCo <0.

View Article and Find Full Text PDF

Background In acne-prone skin, the loss of homeostasis leads to aberrant epithelial differentiation, promoting the formation of microcomedones. The maintenance of sebaceous stem cell homeostasis has emerged as a new therapeutic target in acne management. Objective: The aim of this study is to evaluate the efficacy, tolerability, and safety of a topical formulation combining retinaldehyde, glycolic acid, and Silybum marianum fruit extract for the treatment of acne vulgaris.

View Article and Find Full Text PDF

Background: Cognitive and psychological inflexibility are two mental processes that influence how a person interprets and responds to esophageal symptoms. Patients with greater mental inflexibility are at risk for poorer outcomes. Brain-gut behavioral therapies (BGBT) are effective adjunctive treatments in many digestive diseases, with potential to improve mental flexibility.

View Article and Find Full Text PDF