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http://dx.doi.org/10.1016/j.brs.2024.11.008 | DOI Listing |
Cancer Immunol Immunother
September 2025
Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, CHUV/UNIL, 1011, Lausanne, Switzerland.
Background: Immunotherapy is a mainstay in the treatment of patients with advanced melanoma. Yet, resistance mechanisms exist, and tumour-associated macrophages (TAMs), particularly the M2-like phenotype, are associated with poorer outcomes, with CD206 serving as their specific marker. We present the first human SPECT/CT study to visualize CD206 + TAMs in patients undergoing immunotherapy and compare the findings to clinical outcomes (NCT04663126).
View Article and Find Full Text PDFBackground: Central centrifugal cicatricial alopecia (CCCA) is a scarring alopecia primarily affecting Black women. To date, there are no standardized treatment regimens or approved medications for the treatment of CCCA. This single-center, open-label, clinical study investigated the efficacy of apremilast in the treatment of mild to moderate vertex-predominant CCCA.
View Article and Find Full Text PDFBlood Adv
September 2025
University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Postpartum hemorrhage (PPH) affects up to 44% of women with von Willebrand disease (VWD) despite recombinant VWF (rVWF) treatment. As tranexamic acid (TXA) reduced PPH-related deaths in the WOMAN trial, we assessed whether TXA combined with rVWF versus rVWF alone prevents PPH in VWD. VWD-Woman, a phase 3, open-label, randomized pilot trial, enrolled pregnant women ≥18 years with VWD (VWF:RCo <0.
View Article and Find Full Text PDFCureus
August 2025
Dermatology, Pierre Fabre Dermocosmetics Brazil, São Paulo, BRA.
Background In acne-prone skin, the loss of homeostasis leads to aberrant epithelial differentiation, promoting the formation of microcomedones. The maintenance of sebaceous stem cell homeostasis has emerged as a new therapeutic target in acne management. Objective: The aim of this study is to evaluate the efficacy, tolerability, and safety of a topical formulation combining retinaldehyde, glycolic acid, and Silybum marianum fruit extract for the treatment of acne vulgaris.
View Article and Find Full Text PDFNeurogastroenterol Motil
August 2025
Division of Gastroenterology & Hepatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Background: Cognitive and psychological inflexibility are two mental processes that influence how a person interprets and responds to esophageal symptoms. Patients with greater mental inflexibility are at risk for poorer outcomes. Brain-gut behavioral therapies (BGBT) are effective adjunctive treatments in many digestive diseases, with potential to improve mental flexibility.
View Article and Find Full Text PDF