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Exercise pulmonary hypertension has been invasively defined as mean pulmonary artery pressure/cardiac output slope greater than 3 mm Hg/L/min. Recent advances suggest the sustainable role of exercise Doppler echocardiography for the study of the right heart and pulmonary circulation unit (RH-PCU). Herein, the authors review the invasive versus non-invasive monitoring of the RH-PCU response to exercise in healthy subjects.
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http://dx.doi.org/10.1016/j.hfc.2024.06.001 | DOI Listing |
Philos Trans A Math Phys Eng Sci
September 2025
Department of Mathematics, University of California Davis, Davis, CA, USA.
Many different microswimmers propel themselves using flagella that beat periodically. The shape of the flagellar beat and swimming speed have been observed to change with fluid rheology. We quantify changes in the flagellar waveforms of in response to changes in fluid viscosity using (i) shape mode analysis and (ii) a full swimmer simulation to analyse how shape changes affect the swimming speed and to explore the dimensionality of the shape space.
View Article and Find Full Text PDFJ Cachexia Sarcopenia Muscle
September 2025
Integrative Muscle Biology Laboratory, Division of Rehabilitation Sciences, College of Health Professions, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Background: Cancer promotes muscle wasting through an imbalance in the tightly regulated protein synthesis and degradation processes. An array of intracellular signalling pathways, including mTORC1 and AMPK, regulate protein synthesis, and these pathways are responsive to the muscle's microenvironment and systemic stimuli. Although feeding and fasting are established systemic regulators of muscle mTORC1 and protein synthesis, the cancer environment's impact on these responses during cachexia development is poorly understood.
View Article and Find Full Text PDFBMC Med Educ
September 2025
Department of Prosthodontics, University of Würzburg, Pleicherwall 2, 97070, Würzburg, Germany.
Background: Bridge preparation skills are a vital component of dental education and require specific techniques. This study aimed to develop and evaluate 3D printed teeth for use in defect-oriented bridge preparation and pre-prosthetic exercises in dental training, addressing the limited customization and lack of integrated workflows found in commercial typodont teeth. The null hypothesis stated that 3D printed teeth offered no advantage over established typodont training methods for bridge preparation.
View Article and Find Full Text PDFJ Sci Med Sport
August 2025
Eastern Health Clinical School, Monash University, Australia; Eastern Health Emergency Medicine Program, Australia. Electronic address:
Objectives: To explore differences in beliefs towards running in adults with and without chronic low back pain.
Design: This convergent mixed methods cross-sectional study compared adults with chronic low back pain (n = 39) to pain-free adults with a history of chronic low back pain (n = 28) and a low back pain naive control group (n = 71).
Methods: Beliefs towards running (activity specific beliefs questionnaire; range: 1-4 points), pain intensity (101-point visual analogue scale), disability (Oswestry Disability Index), and habitual physical activity (International Physical Activity Questionnaire) were analysed.
Br J Anaesth
September 2025
MSk Lab, Imperial College London, London, UK; Theatres and Anaesthetics, Imperial College Healthcare NHS Trust, London, UK. Electronic address:
Background: The mechanisms contributing to epidural-related maternal hyperthermia remain unclear. One explanation is that blockade of cholinergic sympathetic nerves prevents active vasodilation and sweating. However, it is not known how labour epidural analgesia affects cutaneous sympathetic function.
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