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Patients surviving critical illness are at risk of persistent physical impairments related to Post Intensive Care Syndrome. Physical impairments and symptoms have potential for recovery, but frequently impact quality of life, performance of activities of daily living and participation in societal roles. Patient and illness-related risk factors directly relate and may predict physical functional outcomes providing opportunity for clinicians and scientist to develop targeted intervention strategies. Clinicians and scientists should screen and assess physical impairments and symptoms early following Intensive care unit discharge with a serial approach to promote for targeted and individualized treatment.
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http://dx.doi.org/10.1016/j.ccc.2024.08.004 | DOI Listing |
JAMA Netw Open
September 2025
Department of Psychiatry, Psychosomatics, and Psychotherapy, University of Lübeck, Lübeck, Germany.
Importance: Patients with inflammatory rheumatic diseases (IRDs) frequently experience psychological distress; however, access to psychological support remains limited.
Objective: To investigate the effectiveness of a digital psychological intervention for individuals with IRDs.
Design, Setting, And Participants: Participants aged 18 years or older were recruited across Germany between February 22 and June 4, 2024, if they had been diagnosed with rheumatoid arthritis, psoriatic arthritis, or systemic lupus erythematosus and reported psychological distress and reduced quality of life.
FASEB J
September 2025
Department of Surgery, McMaster University, Hamilton, Ontario, Canada.
Severe burns are a major global health concern, and are associated with long-term physical and psychological impairments, multi-organ dysfunction, and substantial morbidity and mortality. While burn injuries in adults trigger systemic immuno-metabolic alterations-characterized by white adipose tissue browning, elevated resting energy expenditure, widespread catabolism, and inflammation-these adaptive responses are considerably impaired in older adults, with molecular mechanisms behind these differences remaining largely unclear. As a key regulator of systemic metabolism, investigating the pathological role of adipose tissue (AT) postburn may reveal novel targets that could potentially improve patient outcomes.
View Article and Find Full Text PDFDisabil Rehabil
September 2025
Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada.
Purpose: To develop a comprehensive ICF Core Set (ICF-CS) for vertebral fragility fracture.
Materials And Methods: The development of ICF-CSs involves three phases: i) systematic literature review and qualitative studies; ii) linking process to identify the ICF codes and categories; iii) international consensus process. i) We performed a literature search and qualitative studies with people with vertebral fragility fractures and healthcare professionals; ii) We linked the findings from the search and qualitative studies to the ICF categories, and drafted the proposed ICF-CS; iii) We performed an international consensus process involving experts with clinical or research experience in management of vertebral fragility fractures.
J Cardiovasc Pharmacol
September 2025
Robert M. Berne Cardiovascular Research Center, and Division of Cardiology, University of Virginia, Charlottesville, Virginia, United States.
Cardiorespiratory fitness (CRF) in heart failure (HF) declines with age. Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging and HF. We aimed to determine the changes in CRF before and after treatment with anakinra, recombinant IL-1 receptor antagonist, in patients with HF stratified according to age below and above 60 years in phase II clinical trials.
View Article and Find Full Text PDFEur J Neurol
September 2025
Department of Neurology and Center for Translational and Behavioral Neurosciences, University Medicine Essen, University of Duisburg-Essen, Essen, Germany.
Background: Changes in handgrip strength have recently been adapted as clinical biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) under the assumption of a disease-specific peripheral neuromuscular dysfunction. However, some have proposed that strength impairments in ME/CFS are better explained by alterations in higher-order motor control. In serial measurements, exertion can been assessed through analysis of variation, since maximal voluntary contractions exhibit lower coefficients of variation (CV) than submaximal contractions.
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