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http://dx.doi.org/10.1002/14651858.ED000170 | DOI Listing |
Neurology
October 2025
Montreal Neurological Institute-Hospital, McGill University, Montreal, Canada.
Background And Objectives: Years before diagnosis of Parkinson disease (PD), dementia with Lewy bodies (DLB), or multiple system atrophy (MSA), mild prodromal manifestations can be detected. Longitudinal follow-up of people with prodromal synucleinopathy, particularly idiopathic/isolated REM sleep behavior disorder (iRBD), enables in-depth clinical phenotyping of early disease, which could facilitate stratification for clinical trials, provide the definition of appropriate end points, or predict phenoconversion more precisely. The aim of this study was to update and expand on previous studies assessing clinical evolution from iRBD to clinically diagnosed disease, up to 14 years before diagnosis.
View Article and Find Full Text PDFPLoS Pathog
September 2025
Institut de Chimie des Substances Naturelles, CNRS, Université Paris-Saclay, Gif-sur-Yvette, France.
Respiratory syncytial virus (RSV), the most common cause of bronchiolitis and pneumonia in infants, elicits a remarkably weak innate immune response. This is partly due to type I interferon (IFN) antagonism by the non-structural RSV NS1 protein. It was recently suggested that NS1 could modulate host transcription via an interaction with the MED25 subunit of the Mediator complex.
View Article and Find Full Text PDFBr J Dermatol
September 2025
Clinical Oncology, Guy's and Thomas' NHS Foundation Trust, London, uk.
Background: Primary Cutaneous CD4+ Small Medium T Cell Lymphoproliferative Disorder (PCSM-TLPD) is a rare subtype of indolent lymphoproliferative disease. The treatment, investigations and follow-up protocol are being re-evaluated.
Objective: To use our service evaluation to understand the presentation, response rate, relapse rate, treatment variation, progression free and overall survival of our cohort.
J Exp Psychol Gen
September 2025
Graduate School of Frontier Biosciences, University of Osaka.
Everyday decision making often involves choosing between multiple alternatives, and developing unified theories for this process would benefit broad disciplines of behavioral science. A key challenge lies in explaining behavioral irrationalities that arise specifically in multialternative decisions. This study, based on preregistered procedures, investigated such nonnormative behaviors in a three-choice dot numerosity discrimination task.
View Article and Find Full Text PDFJ Xray Sci Technol
September 2025
Center for Medical Artificial Intelligence, Shandong University of Traditional Chinese Medicine, Qingdao, China.
Parkinson's disease (PD) is a challenging neurodegenerative condition often prone to diagnostic errors, where early and accurate diagnosis is critical for effective clinical management. However, existing diagnostic methods often fail to fully exploit multimodal data or systematically incorporate expert domain knowledge. To address these limitations, we propose MKD-Net, a multimodal and knowledge-driven diagnostic framework that integrates imaging and non-imaging clinical data with structured expert insights to enhance diagnostic performance.
View Article and Find Full Text PDF