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Diffractive achromats (DAs) combined with image processing algorithms offer a promising lens solution for high-performance ultra-thin imagers. However, the design of large-aperture DAs that align seamlessly with image processing algorithms remains challenging. Existing sequential methods, which prioritize focusing efficiency in DAs before selecting an algorithm, may not achieve a satisfactory match due to an ambiguous relationship between efficiency and final imaging quality. Conversely, image-quality-oriented end-to-end design often entails high computational complexity for both front-end optics and back-end algorithms, impeding the development of large-aperture designs. To address these issues, we present a hybrid design scheme that begins with end-to-end optimization of the DA with the simplest image processing algorithm, i.e., Wiener filter, significantly reducing the back-end complexity. Subsequently, we apply complex algorithm fine-tuning to further enhance image quality. We validate this hybrid design scheme through extensive investigations on several DA imagers. Our results demonstrate a reduction in memory requirement by approximately 50 while maintaining a high imaging quality with a reasonably large aperture. As a case in point, we simulated a DA imager with a 25 mm diameter aperture. Furthermore, our hybrid design scheme provides two crucial insights. Firstly, we find no strong linear correlation between focusing efficiency and imaging quality, which challenges the conventional understanding. Secondly, we establish a prediction formula for imaging quality, benefiting from the hybrid design scheme.
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http://dx.doi.org/10.1364/OE.525558 | DOI Listing |
RSC Adv
September 2025
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University Zagazig 44511 Egypt
A novel isatin-thiazole-coumarin hybrid and three isatin-hydantoin hybrids were synthesized and assessed for their α-glucosidase and anticholinesterase inhibitory activities. Moreover, their anticancer properties have been observed against the breast cancer cell lines MCF-7 and MDA-MB-231. The coumarin-containing hybrid exhibited the most potent biological activity across all assays.
View Article and Find Full Text PDFRSC Adv
September 2025
Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University P. O. 43713 New Galala Egypt
Isatin (1-indole-2,3-dione) is a privileged nitrogen-containing heterocyclic framework that has received considerable attention in anticancer drug discovery owing to its general biological behavior and structural diversity. This review focuses on isatin-heterocyclic hybrids as a valuable model in the development of new anti-cancer drugs that may reduce side effects and help overcome drug resistance, discussing their synthetic approaches and mechanism of action as apoptosis induction through kinase inhibition. With various chemical modifications, isatin had an excellent ability to build powerful isatin hybrids and conjugates targeting multiple oncogenic pathways.
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September 2025
Department of Chemistry, Central University of Karnataka Kalaburagi-585 367 Karnataka India.
This research work details the use of a molecular hybridization technique to create a library of four series of hydrazineyl-linked imidazo[1,2-]pyrimidine-thiazole derivatives. The structure of one of the final products, K2, was validated using single-crystal X-ray diffraction. Twenty-six novel hybrid molecules (K1-K26) were synthesized and tested for activity against the H37Rv strain.
View Article and Find Full Text PDFTransl Anim Sci
August 2025
Department of Animal Science, South Dakota State University, Brookings, SD 57007, USA.
This experiment evaluated the effects of replacing one-third of corn grain in a finishing diet with rye grain (RG) processed using one of three processing methods. Predominately Angus steers (n = 192, initial shrunk BW = 410 ± 20.9 kg) were blocked by source and pen location and assigned to one of four dietary treatments: dry-rolled corn (DRC), unprocessed RG (UNP), dry-rolled RG (DRR) and hammer-milled RG (HMR).
View Article and Find Full Text PDFIEEE Nanotechnol Mater Devices Conf
October 2024
PacTech USA Inc., Santa Clara, CA 95050 USA.
Nanoparticles exhibit optical and infrared sensitivity useful in optoelectronics, spectroscopy, and sensing. Capacitative and conductive coupling induces dipolar and charge transfer plasmon modes in nanoscale dimers. Optical and infrared activity of these hybridized modes are exquisitely sensitive to geometric features of the nanoscale dimer.
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