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This study aimed to evaluate the accuracy and efficiency of ChatGPT-3.5, ChatGPT-4o, Google Gemini, and Google Gemini Advanced in generating CAD-RADS scores based on radiology reports. This retrospective study analyzed 100 consecutive coronary computed tomography angiography reports performed between March 15, 2024, and April 1, 2024, at a single tertiary center. Each report containing a radiologist-assigned CAD-RADS score was processed using four large language models (LLMs) without fine-tuning. The findings section of each report was input into the LLMs, and the models were tasked with generating CAD-RADS scores. The accuracy of LLM-generated scores was compared to the radiologist's score. Additionally, the time taken by each model to complete the task was recorded. Statistical analyses included Mann-Whitney U test and interobserver agreement using unweighted Cohen's Kappa and Krippendorff's Alpha. ChatGPT-4o demonstrated the highest accuracy, correctly assigning CAD-RADS scores in 87% of cases (κ = 0.838, α = 0.886), followed by Gemini Advanced with 82.6% accuracy (κ = 0.784, α = 0.897). ChatGPT-3.5, although the fastest (median time = 5 s), was the least accurate (50.5% accuracy, κ = 0.401, α = 0.787). Gemini exhibited a higher failure rate (12%) compared to the other models, with Gemini Advanced slightly improving upon its predecessor. ChatGPT-4o outperformed other LLMs in both accuracy and agreement with radiologist-assigned CAD-RADS scores, though ChatGPT-3.5 was significantly faster. Despite their potential, current publicly available LLMs require further refinement before being deployed for clinical decision-making in CAD-RADS scoring.
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http://dx.doi.org/10.1007/s10278-024-01328-y | DOI Listing |
Br J Radiol
September 2025
Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Objectives: Determine differences in quantitative stenosis severity measurements for ultra-high-resolution (UHR) photon-counting-detector (PCD) coronary CT angiography (cCTA) relative to energy-integrating-detector (EID) cCTA in a large patient cohort.
Methods: Adult participants seen between November 2022 and March 2023 underwent a clinical dual-source EID-CT cCTA and a research dual-source PCD-CT cCTA on the same day. Percent diameter stenosis (PDS) was measured, and stenosis severity was assigned based on the PDS of the most severe lesion per patient to determine a coronary-artery-disease reporting and data system (CAD-RADS) score.
Diagnostics (Basel)
August 2025
Clinic of Cardiology, Mureș County Emergency Clinical Hospital, 540136 Târgu Mureș, Romania.
Atrial fibrillation (AF) is associated with increased epicardial adipose tissue (EAT), atrial dilation, and coronary inflammation, though causality remains unclear. Cardiac computed tomography (CCT) allows for precise quantification of EAT volume and the left atrial volume index (LAVI), along with the calculation of the fat attenuation index (FAI), indicating coronary inflammation. Combined with the Coronary Artery Disease-Reporting and Data System (CAD-RADS), these imaging markers may improve AF risk stratification.
View Article and Find Full Text PDFLife (Basel)
August 2025
Clinic of Cardiology, Mureș County Emergency Clinical Hospital, 540136 Târgu Mureș, Romania.
Background: Coronary artery calcium (CAC) scores are a widely used surrogate marker for atherosclerotic burden, but they do not fully reflect plaque vulnerability or coronary inflammation. This study aimed to evaluate the relationship between CACs, coronary plaque characteristics, and perivascular inflammatory activity using advanced CCTA and CaRi-Heart analysis.
Methods: A total of 250 patients with no prior cardiovascular disease were retrospectively evaluated and stratified by CACs into three groups: 0 ( = 28), 1-100 ( = 121), and >100 ( = 101).
Eur Radiol Exp
August 2025
Department of Radiology, Medical University of Innsbruck, Innsbruck, Austria.
Background: Dual-energy computed tomography (DECT) detects monosodium urate (MSU) deposits in joints. However, the correlation between coronary atherosclerosis phenotypes and MSU-positive lesions in the cardiovascular system remains unclear. We investigated the correlation between coronary MSU-positive plaques on unenhanced DECT with the coronary atherosclerosis profile at coronary CT angiography.
View Article and Find Full Text PDFRadiol Med
August 2025
Total Quality Management Institute, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, #85 Wujin Rd, Shanghai, 200080, China.
Purpose: To investigate the radiomic phenotype of epicardial adipose tissue (EAT) derived from coronary artery calcium score (CACS) and its predictive value for myocardial ischemia.
Materials And Methods: This retrospective study included patients with angina and intermediate-to-high pre-test probability of coronary artery disease who underwent CACS, dynamic CT myocardial perfusion imaging (CT-MPI) and coronary CT angiography (CCTA). All image acquisitions were performed with third generation dual source CT.