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Article Abstract
(Group ) strain COH1 is a representative strain of serotype III, multi-locus sequence type 17, which is disproportionately associated with neonatal meningitis. Here we report the transcriptome of COH1 when interacting with human brain endothelial cells compared with COH1 alone.
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| http://dx.doi.org/10.1128/mra.00455-24 | DOI Listing |
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Unlabelled: Group B Streptococcus (GBS), a common colonizer of the human genital and gastrointestinal tracts, is a leading cause of neonatal bacterial meningitis, which can lead to severe neurological complications. The hypervirulent serotype III, sequence type 17 (ST-17) strain COH1 is strongly associated with late-onset disease due to its unique set of virulence factors. However, genetic manipulation of ST-17 strains is notoriously challenging, limiting the ability to study key pathogenic genes.
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Microb Pathog
October 2025
Department of Laboratory Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China. Electronic address:
Introduction: The hypervirulent ST-17 clone of Group B Streptococcus (GBS) is a leading cause of neonatal invasive meningitis. The link between GBS biofilm formation and the ST-17 lineage is established, and the inhibition of GBS biofilm formation by CsrR involves the regulation of adhesins. However, the specific adhesins involved in biofilm formation in ST-17 GBS strains are unknown.
View Article and Find Full Text PDFstrain COH1 transcriptome in association with stem cell-derived brain-like endothelial cells.
Microbiol Resour Announc
December 2024
Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama, USA.
(Group ) strain COH1 is a representative strain of serotype III, multi-locus sequence type 17, which is disproportionately associated with neonatal meningitis. Here we report the transcriptome of COH1 when interacting with human brain endothelial cells compared with COH1 alone.
View Article and Find Full Text PDFDiet influences community dynamics following vaginal group B streptococcus colonization.
Microbiol Spectr
June 2024
Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
The vaginal microbiota plays a pivotal role in reproductive, sexual, and perinatal health and disease. Unlike the well-established connections between diet, metabolism, and the intestinal microbiota, parallel mechanisms influencing the vaginal microbiota and pathogen colonization remain overlooked. In this study, we combine a mouse model of strain COH1 [group B (GBS)] vaginal colonization with a mouse model of pubertal-onset obesity to assess diet as a determinant of vaginal microbiota composition and its role in colonization resistance.
View Article and Find Full Text PDFDysregulated monocyte-derived macrophage response to Group B in newborns.
Front Immunol
December 2023
Clinic of Neonatology, Department Mother-Woman-Child, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Introduction: (Group B , GBS) is a leading pathogen of neonatal sepsis. The host-pathogen interactions underlying the progression to life-threatening infection in newborns are incompletely understood. Macrophages are first line in host defenses against GBS, contributing to the initiation, amplification, and termination of immune responses.
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