Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Bupropion is a norepinephrine-dopamine reuptake inhibitor that is commonly used as an antidepressant and for smoking cessation. Bupropion overdose can lead to serious side effects which include seizures, status epilepticus, and fatal arrhythmias. Managing bupropion toxicity is challenging as there is no effective antidote and treatment is largely supportive. In this article, we present a case of bupropion toxicity causing profound cardiogenic shock which was treated successfully with mechanical circulatory support.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11545766 | PMC |
| http://dx.doi.org/10.7759/cureus.71137 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Poisonings with antidepressants].
Lakartidningen
September 2025
med dr, överläkare, Giftinformationscentralen.
In 2019 the Swedish Poisons Information Centre (SPIC) was contacted in 1 198 hospital cases of intentional poisonings with antidepressants. Severe poisonings identified using the Poison Severity Score were divided by the number of prescriptions for the respective antidepressant per 1 000 inhabitants, yielding a substance specific poisoning severity index (PSI). Amitriptyline, clomipramine, venlafaxine and bupropion had PSIs surpassing all other antidepressants by nearly an order of magnitude and comprised almost 80% of 101 serious poisonings.
View Article and Find Full Text PDFConcomitant Use of Dextromethorphan/Bupropion and Escitalopram Associated With Serotonin Toxicity in an Older Adult: A Case Report.
J Clin Psychopharmacol
August 2025
Department of Psychiatry, University of Pennsylvania Perelman School of Medicine Philadelphia, PA.
Serotonin Syndrome Without Overdose: Polypharmacy-Induced Toxicity in a Medically Stable Young Adult.
Cureus
June 2025
Osteopathic Medicine/Family Medicine, Lake Erie College of Osteopathic Medicine, Elmira, USA.
Serotonin syndrome is a potentially life-threatening condition caused by excessive serotonin activity in the central and peripheral nervous systems that can lead to symptoms such as altered mental status, autonomic instability (e.g., hyperthermia and hypertensive tachycardia), and neuromuscular abnormalities (e.
View Article and Find Full Text PDFPhenoconversion and phenotyping of hepatic cytochrome P450: Implications in predictive precision medicine and personalized therapy.
Hepatol Forum
September 2024
Department of Gastroenterology, Firat University School of Medicine, Elazig, Turkiye.
Drug dose efficacy/toxicity depends on a number of factors including genetic and nongenetic factors, a pre-existing disease, and coadministration of other substances and drugs. Cytochrome P450 (CYP) proteins play a crucial role in drug metabolism where they catalyse a number of Phase I oxidation reactions. Concurrently administered drugs and substances, besides the CYP genotype are crucial and can induce/inhibit the CYP activity, thus affecting drug biotransformation and its bioavailability, compromising with drug efficacy, or even causing toxicity due to slow metabolism.
View Article and Find Full Text PDF