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Purpose: The associations between work time, leisure-time, and non-workday physical activity (PA) and sedentary behavior (SED), and 24-h ambulatory blood pressure (BP) are not well known. Therefore, the aim of this study was to evaluate the associations between domain-specific activity behavior and 24-h BP.
Methods: A hundred fifty-six aging workers (mean age, 62.4 (SD 1.0) yr; body mass index, 26.2 (4.5) kg·m -2 ; 84% women; 75% nonmanual occupation) from the Finnish Retirement and Aging study were included. Standing, light and moderate-to-vigorous PA, and SED were measured using thigh-worn accelerometers and work time, leisure-time, and non-workdays were distinguished using a diary. Ambulatory 24-h BP was analyzed as mean daytime and nighttime systolic and diastolic BP, and the nocturnal BP dipping percentage was calculated. Associations were examined with linear regression analysis adjusting for age, sex, occupation, work time mode, job strain, body mass index, BP medication, and accelerometer wear time.
Results: Higher work time SED was associated with lower nighttime diastolic BP ( B = -0.92; 95% confidence interval (CI), -1.83 to -0.01). In addition, higher work time standing was associated with higher daytime diastolic BP ( B = 1.34; 95% CI, 0.03 to 2.65), and higher work time light PA was associated with less diastolic BP dipping ( B = -3.57; 95% CI, -6.80 to -0.34). Moderate-to-vigorous PA in any domain was not associated with ambulatory BP.
Conclusions: Higher work time SED was associated with a more favorable diastolic BP, and higher work time PA was associated with more adverse diastolic BP among aging workers. In conclusion, work time, rather than leisure time or non-workday, activity behavior seems to be associated with 24-h ambulatory BP.
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http://dx.doi.org/10.1249/MSS.0000000000003594 | DOI Listing |
Spectrochim Acta A Mol Biomol Spectrosc
September 2025
College of Chemistry, Chemical Engineering and Material Science, Soochow University, No. 199 Ren'Ai Road, Suzhou 215123, China; Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Science, Suzhou 215163, China. Electronic address: g
The dynamic monitoring of cell death processes remains a significant challenge due to the scarcity of highly sensitive molecular tools. In this study, two hemicyanine-based probes (5a-5b) with D-π-A structures were developed for organelle-specific viscosity monitoring. Both probes exhibited correlation with the Förster-Hoffmann viscosity-dependent relationship (R > 0.
View Article and Find Full Text PDFThromb Res
September 2025
Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. Electronic address:
Warfarin is a widely used vitamin K antagonist (VKA) with known pleiotropic effects beyond anticoagulation. Preclinical and case-control evidence suggests that warfarin may affect hematopoiesis, but longitudinal human evidence is lacking. To explore this potential effect, we conducted a post-hoc analysis of participants in the Hokusai-VTE and ENGAGE AF-TIMI 48 trials, which randomized patients to warfarin or the direct oral anticoagulant edoxaban with routine laboratory testing at predefined follow-up visits.
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View Article and Find Full Text PDFObjectiveThis work examined performance costs for a spatial integration task when two sources of information were presented at increasing eccentricities with an augmented-reality (AR) head-mounted display (HMD).BackgroundSeveral studies have noted that different types of tasks have varying costs associated with the spatial proximity of information that requires mental integration. Additionally, prior work has found a relatively negligible role of head movements associated with performance costs.
View Article and Find Full Text PDFPLoS Genet
September 2025
Department of Biochemistry, Indian Institute of Science, Bengaluru, Karnataka, India.
Tropomyosin is an actin-binding protein (ABP) which protects actin filaments from cofilin-mediated disassembly. Distinct tropomyosin isoforms have long been hypothesized to differentially sort to subcellular actin networks and impart distinct functionalities. Nevertheless, a mechanistic understanding of the interplay between Tpm isoforms and their functional contributions to actin dynamics has been lacking.
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