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One of the most frequent conditions found in the oral cavity includes reactive lesions. Peripheral ossifying fibroma (POF) is a prevalent condition characterized by an overgrowth, originating from the gingival tissue, periodontal ligament, and periosteum. The condition manifests as a small mucosal nodule and can be difficult to accurately identify since it resembles other lesions. Chronic irritation and trauma are considered to be etiological agents. It is more prevalent in females and typically impacts the anterior region of the maxilla and mandible. The recommended therapy for POF involves surgical excision and eliminating any factors that may be causing irritation in the affected area. It can grow significantly if not surgically removed early. Treatment is necessary to prevent recurrence. It can be misdiagnosed due to overlapping features with other lesions. Correct biopsy technique and histopathological evaluation are crucial for accurate diagnosis. This case report illustrates the management of gingival overgrowth in an 18-year-old female patient after comprehensive clinical evaluation by using conventional surgical excision with the help of a scalpel. The final diagnosis of POF was confirmed using histopathologic evaluation. The treatment led to favorable outcomes in the patient regarding mastication, speech, and esthetics.
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http://dx.doi.org/10.7759/cureus.70818 | DOI Listing |
Mod Pathol
July 2025
Department of Pathology, University of Miami and Miller School of Medicine, Miami, Florida.
This investigation describes the clinicoradiologic, pathologic, and molecular features of a unique soft tissue tumor characterized by a peripheral shell of bone and composed of bland myoid spindle and epithelioid cells that are keratin-positive. Our study cohort consists of 6 men and 6 women, with a mean age of 32 years. The tumors arose in the extremities (n = 9) and proximal limb girdle (n = 3) and were equally distributed between deep and superficial soft tissues.
View Article and Find Full Text PDFDiagnostics (Basel)
June 2025
Department of Surgical Pathology, Medicine, Molecular and Critical Area, University of Pisa, Via Roma 67, 56126 Pisa, Italy.
Amelanotic melanocytic nevi of the oral cavity are uncommon lesions that often present a diagnostic challenge for clinicians, primarily due to their nonspecific clinical appearance and the broad spectrum of possible differential diagnoses. These lesions can mimic a variety of benign and malignant conditions, requiring precise histopathological confirmation. The primary objective of this article is to present a comprehensive case report-tracing the course from initial presentation through diagnostic workup to final diagnosis-and to provide an overview of the current literature on oral amelanotic melanocytic nevi.
View Article and Find Full Text PDFCureus
May 2025
Department of Pediatric Dentistry, Faculty of Dental Medicine, Mohammed V University in Rabat, Rabat, MAR.
Pyogenic granuloma (PG) is a benign vascular lesion that manifests as an inflammatory hyperplasia of the skin or mucous membranes. Although termed "pyogenic," PG is not associated with infection; rather, it represents a reactive lesion arising in response to various stimuli such as low-grade local irritation, trauma, or hormonal influences. Clinically, PGs are typically asymptomatic and display variable growth rates.
View Article and Find Full Text PDFCancers (Basel)
April 2025
Neurosurgery Unit, Department of Head and Neck Surgery, Garibaldi Hospital, 95124 Catania, Italy.
Ossifying fibromyxoid tumors (OFMTs) are rare mesenchymal neoplasms with behaviors ranging from benign to malignant. Although most occur in the extremities and trunk, 9-13% are found in the head and neck, such as the oral cavity, scalp, and calvarium. Diagnosis is challenging due to their rarity and histological similarity to other neoplasms.
View Article and Find Full Text PDFHead Neck Pathol
May 2025
Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.
Introduction: Ameloblastic fibroma (AF), ameloblastic fibrodentinoma (AFD), and ameloblastic fibro-odontoma (AFO) are rare mixed odontogenic tumors. While some authors propose that some cases may evolve into odontomas, other tumors with aggressive clinical features suggest a neoplastic origin. A subset of AF and AFD/AFO harbor the pathogenic BRAF p.
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