Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background & Aims: The diagnostic criteria for cachexia, as proposed by the Asian Working Group for Cachexia (AWGC), include weight loss, a low body mass index, and additional factors such as a low handgrip strength (HGS), anorexia, or elevated CRP levels. This study aimed to evaluate the significance of low HGS as a diagnostic criterion in patients with advanced cancer.
Methods: This single-centre, retrospective cohort study was conducted between April 2019 and March 2023. Patients aged ≥18 years with malignant diseases were included. Patients without records on HGS were excluded. Low HGS was defined as a HGS <28 kg for men and <18 kg for women. The overall median survival time (MST) was analysed by univariate and multivariate analyses.
Results: A total of 894 patients were analysed. Cachexia was prevalent in 74 %, though only 3.4 % were diagnosed based solely on low HGS. The MST in patients with cachexia was 122 days, and in those with low HGS was 73 days. The associations between low HGS and high mortality remained significant after adjusting for AWGC criteria, modified weight loss grading system, age, gender, performance status, calf circumferenceand fluid retention. The MST varied with the number of additional factors being met: 422 days for one criterion, 92 days for two, and 55 days for all three (p < 0.0001).
Conclusion: This study supports that HGS serve as important prognostic tool in patients with various cancers.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.clnesp.2024.10.162 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phase angle is related to physical function in high-risk Dutch older adults: implications for sarcopenia screening.
J Frailty Aging
September 2025
Division of Human Nutrition and Health, Wageningen University, P.O. Box 17, 6700, AA, Wageningen, Netherlands.
Introduction: Sarcopenia, a progressive age-related loss of skeletal muscle mass and function, poses significant health risks in older adults. Phase angle (PhA), derived from bioimpedance analysis, has been proposed as an indicator of muscle quality and physical functioning. This study investigates the association between PhA and physical function, and its potential utility in case-finding phase of sarcopenia assessment based on EWGSOP2 functional cut-offs.
View Article and Find Full Text PDFAssociation Between Oral Health and Probable Sarcopenia in Older Adults: A Cross-Sectional Study.
Int J Gen Med
August 2025
Department of Geriatrics, HSU Balıkesir Atatürk City Hospital, Balıkesir, Turkey.
Background: This study aimed to examine the association between oral health-related quality of life and probable sarcopenia in community-dwelling older adults, and to evaluate the potential role of oral health assessment in routine geriatric care.
Methods: This cross-sectional study included 315 individuals aged ≥65 years who were registered with the Home Health Unit and the Geriatric Outpatient Clinic of a tertiary hospital in Türkiye. Oral health-related quality of life was measured using the Geriatric Oral Health Assessment Index (GOHAI).
Supportive Care Needs From Mid-to Long-Term Follow-Up Among Head and Neck Cancer Survivors: A Longitudinal Cohort Study.
Psychooncology
September 2025
Cancer Center Amsterdam Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Background: There is limited knowledge on the supportive care needs (SCNs) of head and neck cancer (HNC) survivors during long-term survivorship.
Aims: To investigate SCNs from 2 to 5 years after treatment among HNC survivors, and its association with demographic, personal, clinical, physical, psychological, social and lifestyle, and cancer-related quality of life factors.
Methods: SCNs were measured at 2, 3, 4 and 5 years using the supportive care needs survey (SCNS-SF34 and SCNS-HNC) in 403 HNC survivors.
Waist circumference is an important determinant of relative muscle strength in patients with type 2 diabetes mellitus.
J Chin Med Assoc
September 2025
Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.
Background: Muscle damage has recently been recognized as a complication of type 2 diabetes mellitus (T2DM). Impaired muscle function adversely affects physical activity, quality of life, and mortality risk. Moreover, waist circumference (WC) is associated with visceral fat and insulin resistance.
View Article and Find Full Text PDFEffects of digital physical activity interventions on muscle mechanical function in community-dwelling older adults: a systematic review and meta-analysis.
Eur Rev Aging Phys Act
September 2025
University of Southern Denmark, Odense, Denmark.
Aim: To investigate the effect of digital exercise interventions on muscle mechanical function in community-dwelling older adults aged 60 and above.
Methods: Systematic review of randomised controlled trials (RCTs) retrieved from PubMed, EMBASE (Ovid), the Cochrane Central Register of Controlled Trials, and Web of Science until end of March 2024. The Cochrane RoB2.