Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background And Objectives: Meningioma, the most common primary intracranial tumor, presents challenges in surgical treatment because of varying tissue stiffness. This study explores the molecular background of meningioma stiffness, a critical factor in surgical planning and prognosis, focusing on the utility of microRNAs (miRNAs) as diagnostic biomarkers of tissue stiffness.
Methods: Patients with meningiomas treated surgically at the University Hospital Brno were included in this study. Total RNA, isolated from tumor tissue samples, underwent quality control and small RNA sequencing to analyze miRNA expression. Differentially expressed miRNAs were identified, and their association with tumor stiffness was assessed.
Results: This study identified specific miRNAs differentially expressed in meningiomas with different stiffness levels. Key miRNAs, such as miR-31-5p and miR-34b-5p, showed significant upregulation in stiffer meningiomas. These findings were validated using reverse transcription-quantitative polymerase chain reaction, revealing a potential link between miRNA expression and tumor consistency. The expression of miR-31-5p was most notably associated with the stiffness of the tumor tissue (sensitivity = 71% and specificity = 83%).
Conclusion: This research highlights the potential of miRNAs as biomarkers for determining meningioma tissue stiffness. Identifying specific miRNAs associated with tumor consistency could improve preoperative planning and patient prognosis. These findings pave the way for further exploration of miRNAs in the clinical assessment of meningiomas.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970888 | PMC |
| http://dx.doi.org/10.1227/neu.0000000000003222 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The relationship between triceps surae muscle-tendon morphology and shear modulus across passive ankle range of motion in cerebral palsy.
J Biomech
September 2025
Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, Finland. Electronic address:
Alterations in skeletal muscle morphology and composition are critical factors in cerebral palsy (CP), including changes in passive stiffness and in belly and fascicle lengths. In this study, we quantified the relative contributions of muscle and tendon to passive stiffness across the ankle range of motion in individuals with CP and typically developing (TD) peers. We also investigated morphological factors underlying increased muscle stiffness.
View Article and Find Full Text PDFClinicopathologic Features, Pathogenesis, and Treatment of Monoclonal Gammopathy-Associated Myopathies.
Neurology
October 2025
Department of Neurology, Mayo Clinic, Rochester, MN.
Monoclonal gammopathy-associated myopathies (MGAMs) are rare yet treatable myopathies that occur in association with monoclonal gammopathies. These myopathies include light chain (AL) amyloidosis myopathy, sporadic late-onset nemaline myopathy (SLONM), scleromyxedema with associated myopathy, and newly reported monoclonal gammopathy-associated glycogen storage myopathy (MGGSM), including the vacuolar myopathy with monoclonal gammopathy and stiffness. All these 4 distinct subtypes of MGAMs typically present in patients aged 40 or older, frequently with a subacute onset of rapidly progressive proximal and axial muscle weakness.
View Article and Find Full Text PDFMultiscale Engineered Heterogeneous Hydrogel Composites for Digital Light Processing 3D Printing.
ACS Appl Mater Interfaces
September 2025
Department of Materials Science and Engineering, College of Engineering, Texas A&M University, College Station, Texas 77843, United States.
Hydrogel-based bioinks are widely adopted in digital light processing (DLP) 3D printing. Modulating their mechanical properties is especially beneficial in biomedical applications, such as directing cell activity toward tissue regeneration and healing. However, in both monolithic and granular hydrogels, the tunability of mechanical properties is limited to parameters such as cross-linking or packing density.
View Article and Find Full Text PDFExperience and Challenges in Intraocular Surgery in Patients With Kyphosis: A Cross-Sectional Survey Among Practicing Ophthalmologists.
Cureus
August 2025
Community Medicine, Patna Medical College, Patna, IND.
Background: The practice patterns for patient positioning, surgical techniques, and challenges faced by ophthalmologists during eye surgery on patients with kyphosis in India are yet unknown.
Methods: A cross-sectional online survey was conducted through Google Forms amongst practicing ophthalmic surgeons over two months and communicated across email lists and social media networks of state and regional ophthalmological associations of India in 2022.
Results: Fifty-two ophthalmologists responded (mean age 48.
Modification of the Middle Cerebral Artery Bifurcation Angle Using a Stiff 0.014-Inch Microguidewire for Enhanced Woven EndoBridge Device Deployment.
Cureus
August 2025
Neurosurgery, Hyogo Medical University, Nishinomiya, JPN.
This report explores the challenges of using the Woven EndoBridge (WEB) (Terumo, Tokyo, Japan) for a middle cerebral artery bifurcation aneurysm and introduces a novel technical approach not previously described in the literature. In a 75-year-old male patient, a stiff microguidewire was used to guide a microcatheter to the distal branch of the middle cerebral artery bifurcation aneurysm to modify the bifurcation angle, ensuring the WEB's stable placement. The patient's postoperative course was uneventful, with magnetic resonance angiogram (MRA) confirming the aneurysm's complete disappearance.
View Article and Find Full Text PDF