Shared and unique lifetime stressor characteristics and network connectivity predict adolescent anxiety and depression.

Background: Exposure to major life stressors and aberrant functional connectivity have been linked to anxiety and depression, especially during adolescence. However, whether specific characteristics of life stressors and functional network connectivity act together to differentially predict anxiety and depression symptoms remains unclear.

Methods: We utilized baseline lifetime stressor exposure and resting-state functional magnetic resonance imaging data in a longitudinal sample of 107 adolescents enriched for anxiety and depressive disorders. We examined five stressor characteristics: physical danger, interpersonal loss, humiliation, entrapment, and role change/disruption. Anxiety and depression symptoms were assessed at baseline, 6-month and 12-month follow-ups. Linear mixed-effect models tested if lifetime severity of these stressor characteristics, functional connectivity within and between frontoparietal, default, and ventral attention networks, and their interactions differentially predicted anxiety and depression symptoms at two 6-month follow-ups.

Results: Greater lifetime severity of physical danger and humiliation predicted higher anxiety symptoms. Greater lifetime entrapment severity predicted higher anxiety and depression symptoms. After including within- and between-network functional connectivity and other predictive characteristics, only the effects of lifetime entrapment severity remained significant. Lifetime entrapment severity more strongly predicted anxiety symptoms in youth with higher default network connectivity. Greater functional connectivity between frontoparietal and default networks predicted increased depression symptoms.

Conclusions: Our study is the first to use lifetime severity of distinct stressor characteristics and resting-state functional connectivity jointly to predict adolescent anxiety and depression symptoms. These results imply certain stressor characteristics and functional connectivity metrics as specific predictors of anxiety or depression and highlight entrapment as a shared predictor for anxiety and depression.