98%
921
2 minutes
20
On October 8 2024, the Royal Swedish Academy of Sciences announced the 2024 Nobel Prize in Physics was awarded to Hopfield and Hinton for their foundation research on machine learning with artificial neural networks, which resulted in the current applications for artificial intelligence (AI). Digital diagnostic histopathology combines image capture with image analysis and uses digital tools to collect, analyze, and share diagnostic information. An increase in chronic diseases, diagnostic departmental workloads, and diagnostic tests to support targeted therapy in cancer patients have driven the use and development of image analysis systems, and several medical device companies have recently developed whole-slide scanning devices. In April 2017, the US Food and Drug Administration (FDA) permitted marketing authorization for the first whole slide imaging (WSI) system. During 2024, large-scale studies from several cancer centers have shown the potential for diagnostic reporting for real-world data and whole-slide modeling to develop validated diagnostic AI algorithms. This editorial discusses why recent advances and applications in AI and digital image analysis may have an important future role in cancer diagnosis and prognosis.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536697 | PMC |
http://dx.doi.org/10.12659/MSM.947038 | DOI Listing |
Mol Pharm
September 2025
Department of Nuclear Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Tissue factor (TF) has emerged as a promising target for the diagnosis and treatment of hepatocellular carcinoma (HCC). However, there is limited data available on TF-related PET imaging for longitudinal monitoring of the pathophysiological changes during HCC formation. Herein, we aimed to explore the TF-expression feature and compare a novel TF-targeted PET probe with F-FDG through longitudinal imaging in diethylnitrosamine (DEN)-induced rat HCC.
View Article and Find Full Text PDFBlood Adv
September 2025
BC Cancer, Vancouver, British Columbia, Canada.
Classical Hodgkin Lymphoma (CHL) is characterized by a complex tumor microenvironment (TME) that supports disease progression. While immune cell recruitment by Hodgkin and Reed-Sternberg (HRS) cells is well-documented, the role of non-malignant B cells in relapse remains unclear. Using single-cell RNA sequencing (scRNA-seq) on paired diagnostic and relapsed CHL samples, we identified distinct shifts in B-cell populations, particularly an enrichment of naïve B cells and a reduction of memory B cells in early-relapse compared to late-relapse and newly diagnosed CHL.
View Article and Find Full Text PDFEur Heart J Cardiovasc Imaging
September 2025
Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Aims: Fetal circulation undergoes complex changes in congenital heart disease (CHD) that are challenging to assess with fetal echocardiography. This study aimed to assess clinical feasibility and diagnostic value of 4D flow cardiac magnetic resonance (CMR) in fetal CHD.
Methods And Results: Pregnant women in advanced third trimester pregnancy with fetal CHD were prospectively recruited for fetal CMR between 08/2021 and 11/2024.
Eur J Endocrinol
September 2025
Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, Minnesota, 55905.
Objective: Identify social/metabolic risk factors associated with subsequent diagnosis of adrenal adenoma.
Design: Population-based historical case-control study.
Methods: Cases were adult patients diagnosed with an adrenal adenoma between 2005-2017 with no overt hormone excess.
PLoS One
September 2025
Center for Radiological Research, Columbia University Irving Medical Center, New York, New York, United States of America.
In the event of a large-scale radiological or nuclear emergency, a rapid, high-throughput screening tool will be essential for efficient triage of potentially exposed individuals, optimizing scarce medical resources and ensuring timely care. The objective of this work was to characterize the effects of age and sex on two intracellular lymphocyte protein biomarkers, BAX and p53, for early radiation exposure classification in the human population, using an imaging flow cytometry-based platform for rapid biomarker quantification in whole blood samples. Peripheral blood samples from male and female donors, across three adult age groups (young adult, middle-aged, senior) and a juvenile cohort, were X-irradiated (0-5 Gy), and biomarker expression was quantified at two- and three-days post-exposure.
View Article and Find Full Text PDF