Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Trazodone, an antidepressant drug is also largely used in several medical contexts. Insomnia, behavioral disorders, and anxiety may be underlying symptoms for prescribing trazodone. This cross-sectional study aims to identify reasons for trazodone prescription, assess the efficacy, as well as identify any related side effects in older persons living in long term care facilities (LTCFs).
Methods: Older adults aged ≥ 60 years, at risk of or affected with Covid-19 and enrolled in the GeroCovid Observational study from LTCFs, and using trazodone were included. A structured questionnaire was administered to treating physicians regarding reasons for trazodone prescription, discontinuation, possible adverse events and benefits.
Results: Thirty-seven out 74 LTCFs participating in both the GeroCovid and GeroCovid Vax studies completed the questionnaire regarding trazodone use. Of the 427 participants included in this study analysis, we found that 43% had diagnoses of dementia and depression, 33% had dementia, no behavioral and psychological symptoms of dementia (BPSD) and no depression, 14% had dementia with BPSD and no depression, and < 11% had only depression. The main reasons for trazodone prescription included agitation, insomnia, depression and anxiety. Trazodone use was reported as partially or totally effective in more than 90% of participants using the drug. Falls were the most frequent adverse event (30% of participants).
Conclusions: Our data suggest that trazodone behaves as an eclectic antidepressant that, in the clinical practice, may also be used for BPSD and insomnia, especially in older people with dementia.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/gps.70009 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of Palatable Amorphous Trazodone Hydrochloride Formulations via Ion Exchange.
Pharmaceutics
July 2025
Wuya College of Innovation, Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
The oral route is the most widely used method of administration. However, the bitter taste of drugs is a prevalent issue compromising patient acceptance. This study aimed to develop a palatable amorphous trazodone hydrochloride (TRA) formulation via ion exchange with Amberlite IRP88 resin as the carrier.
View Article and Find Full Text PDFTrazodone and Risk of Orthostatic Hypotension, Syncope and Falls in Geriatric Outpatients with Hypertension.
Drugs Aging
April 2025
Division of Geriatric and Intensive Care Medicine, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Largo Brambilla 3, 50139, Florence, Italy.
Introduction: In older adults, trazodone is frequently prescribed for anxiety and insomnia owing to its perceived greater tolerability in comparison with benzodiazepines. However, it may have hypotensive effects.
Aim: The aim of this study is to investigate the effects of trazodone on orthostatic blood pressure (BP) response and risk of syncope and falls in hypertensive older adults.
Real-World Use of Trazodone in Older Persons in Long Term Care Setting: A Retrospective Study.
Int J Geriatr Psychiatry
November 2024
Unit of Geriatrics, Department of Medicine, Campus Bio-Medico University and Teaching Hospital, Roma, Italy.
Article Synopsis
- Trazodone, an antidepressant often prescribed for insomnia, anxiety, and behavioral disorders, is the focus of a study aimed at understanding its prescription reasons, effectiveness, and side effects in older adults in long-term care facilities.
- The study included feedback from 37 out of 74 participating long-term care facilities, analyzing data from 427 older adults, revealing that common reasons for prescribing trazodone included agitation, insomnia, and depression, with over 90% reporting it was effective.
- While trazodone proved beneficial, the study identified falls as a key side effect, affecting 30% of participants, underlining the need for careful monitoring in elderly patients, especially those with dementia.
Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial.
JAMA Netw Open
December 2023
National Jewish Health, Denver, Colorado.
Importance: Daytime functional impairments are the primary reasons for patients with insomnia to seek treatment, yet little is known about what the optimal treatment is for improving daytime functions and how best to proceed with treatment for patients whose insomnia has not remitted.
Objectives: To compare the efficacy of behavioral therapy (BT) and zolpidem as initial therapies for improving daytime functions among patients with insomnia and evaluate the added value of a second treatment for patients whose insomnia has not remitted.
Design, Setting, And Participants: In this sequential multiple-assignment randomized clinical trial conducted at institutions in Canada and the US, 211 adults with chronic insomnia disorder were enrolled between May 1, 2012, and December 31, 2015, and followed up for 12 months.
New-onset hallucinations with amiodarone: a case report.
Ann Gen Psychiatry
August 2022
Department of Psychiatry and Behavioral Medicine, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI, 53226, USA.
Background: Amiodarone is a commonly used antiarrhythmic for the treatment of atrial fibrillation with a unique pharmacokinetic profile. While general side effects can be frequently associated with amiodarone, psychiatric adverse reactions to this medication are uncommon. The relationship between amiodarone and hallucinations independent of delirium has been rarely reported in the literature.
View Article and Find Full Text PDF