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Introduction: The identification of geriatric syndromes in people with dementia is important. The aim of the study was to assess the prevalence of geriatric syndromes among dementia outpatients.
Methods: A cross-sectional study was conducted enrolling outpatients with dementia aged ≥60 years old. Dementia was diagnosed by neuropsychiatrists following DSM-5 criteria. The geriatric syndromes assessed included nutritional status (Mini Nutritional Assessment Scale-Short Form), polypharmacy, comorbidities, alcohol use, depression (quality of life in Alzheimer disease), functional status (Barthel Index, Instrumental Activities of Daily Living); lower body strength (30 s stand chair test), and frailty (Timed Up and Go test ≥14 s).
Results: A total of 87 participants was recruited in the study (mean age: 76.8 ± 1.2 years; female: 65.5%). The median number of geriatric syndromes per participant was 5 (IQR = 2); all participants had two or more geriatric syndromes. The most common geriatric syndromes were loss of independence (96.6% impairment in >1 IADL task score and 74.7% dependency in physical function at based on Barthel Index), reduced lower body strength (86.2%), malnutrition and risk of malnutrition (78.2%), and frailty (67.8%). Current and history of smoking, drinking alcohol, using memantine therapy, malnourishment and risk of malnourishment were significantly associated with increasing severity of dementia.
Conclusion: The presence and coincidence of geriatric syndromes is common among outpatients with dementia. These findings have important clinical implications in terms of the assessment and service delivery for older adults in Vietnam. We are exploring ways to enhance our services to provide comprehensive, multidisciplinary approaches to screening, recognition, and treatment of geriatric syndromes in older adults with dementia.
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http://dx.doi.org/10.1159/000541237 | DOI Listing |
Maturitas
September 2025
Department of Geriatrics, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University, Beijing, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Falls are a major cause of disability. Whether exposure to ambient air pollution contributes to the occurrence of falls remains unclear.
Objective: To investigate the cross-sectional and longitudinal associations between ambient air pollution and the risk of falls in a community-dwelling adult population.
Pigment Cell Melanoma Res
September 2025
Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
The diagnostic approaches for Hermansky-Pudlak Syndrome (HPS) include genetic sequencing, immunoblotting, electron microscopy (EM), and flow cytometry with mepacrine staining. However, these methods are often impractical for routine clinical use due to high cost, technical complexity, and limited availability. In this study, we evaluated dense granules (DGs) function in HPS mouse models using flow cytometry with mepacrine and FluoZin-3 staining.
View Article and Find Full Text PDFInn Med (Heidelb)
September 2025
Comprehensive Cancer Center, Universitätsklinik Würzburg, Würzburg, Deutschland.
Frailty is a common geriatric syndrome in older patients with cancer. It affects prognosis and treatment tolerance in various ways. Frailty and cancer share several common risk factors, which are reflected in the hallmarks of aging.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Unlabelled: Bleeding and thromboembolic events (BTE) increase the mortality of COVID-19 acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The current analysis aimed to assess frequency and determinants of BTE according to their location and severity in a retrospective analysis of the German ECMO COVID-19 registry. Logistic regression was applied to identify factors influencing ICU survival as well as variables associated with risks of BTE.
View Article and Find Full Text PDFMed Sci Monit
September 2025
Department of Geriatric Nursing, Medical University of Warsaw, Warsaw, Poland.
BACKGROUND Frailty syndrome (FS) and cognitive impairment are major geriatric concerns, particularly prevalent among hospitalized older adults. The primary objective of this study was to assess the co-occurrence of FS and cognitive impairment in hospitalized geriatric patients. Additionally, the study analyzed the relationship of these conditions with functional status, fall risk, sensory deficits, depressive symptoms, and selected prognostic laboratory parameters.
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