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Background Gestational diabetes mellitus (GDM) has been increasingly associated with heightened cardiovascular and thrombotic risk. This study aimed to evaluate hemostatic and metabolic profiles in women with GDM to explore early markers of vascular dysfunction. Methods A retrospective cross-sectional study was conducted among 250 pregnant women diagnosed with GDM between December 2022 and October 2023 at multiple tertiary healthcare facilities in Pakistan.
View Article and Find Full Text PDFIn vivo Pharmacokinetic Interactions Between Palbociclib and Rivaroxaban or Apixaban: Implications for Increased Drug Exposure and Dose Adjustments.
Drug Des Devel Ther
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Hebei General Hospital, Hebei Key Laboratory of Clinical Pharmacy, Shijiazhuang, 050051, People's Republic of China.
Background: Apixaban and rivaroxaban are oral direct factor Xa inhibitors, primarily eliminated through CYP3A4-mediated metabolism and direct intestinal excretion. Previous studies suggest that palbociclib, a CDK4/6 inhibitor, may increase the systemic exposure of these anticoagulants; however, the specific pharmacokinetic mechanisms remain unclear. This study aims to evaluate the effects of palbociclib on the pharmacokinetics of apixaban and rivaroxaban using a rat model to optimize combined drug regimens.
View Article and Find Full Text PDFEnhancing the Understanding and Utilization of Hypercoagulable Workup: A Quality Improvement Initiative.
Cureus
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Hematology and Medical Oncology, St. Luke's University Health Network, Bethlehem, USA.
Background In hospitalized patients, hypercoagulable testing is frequently overutilized, particularly in the context of acute thrombosis or active anticoagulation, when certain results may be unreliable and are unlikely to affect clinical management. This quality improvement (QI) initiative aimed to improve provider understanding and test utilization through electronic medical record (EMR) changes and targeted education. Methodology A retrospective chart review was performed across the St.
View Article and Find Full Text PDFThe implication of abnormal routine coagulation parameters in Dabie bandavirus infection.
Scand J Clin Lab Invest
August 2025
Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Prolonged activated partial thromboplastin time (APTT) and thrombin time (TT), normal prothrombin time (PT) and elevated D-dimer level are typical manifestation of routine coagulation parameters in patients infected with Dabie bandavirus (DBV), infection-induced coagulation activation and consumption, and a heparin-like effect due to endogenous heparan are the common explanations. To understand the exact implication of abnormal coagulation parameters in patients infected with DBV and their correlation with bleeding tendency and prognosis. One hundred and twenty-one consecutive DBV-infected patients were enrolled in this prospective, single-center, observational study.
View Article and Find Full Text PDF[Clinical study on the effect of glycosaminoglycans on vascular endothelial glycocalyx in sepsis].
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
June 2025
Department of Critical Care Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, Zhejiang, China. Tang Zewen now works in the emergency department of Zhuzhou Central Hospital, Zhuzhou 412007, Hunan, China. Corresponding author: Lin Leqing, Email:
Objective: To explore the protective effect of glycosaminoglycans (GAG) on vascular endothelium in patients with sepsis.
Methods: A prospective study was conducted on adult patients with sepsis admitted to the intensive care unit (ICU) of Hangzhou Normal University Affiliated Hospital from December 2022 to December 2023. Patients were randomly divided into conventional treatment group and GAG intervention group.