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The Coronal Plane Alignment of the Knee (CPAK) classification is a pragmatic distribution of nine phenotypes for coronal knee alignment that can be used on healthy and arthritic knees. Our study aimed to describe the CPAK distributions in a Spanish southeast osteoarthritic population and compare them to other populations' published alignment distributions. Full-leg standing X-rays of the lower limb from 528 cases originating from the so-called Vega Alta del Segura (southeast of the Iberian Peninsula) were retrospectively analysed. We measured the mechanical hip-knee-ankle, lateral distal femoral, and medial proximal tibial angles. We calculated the arithmetic hip-knee-ankle angle and the joint line obliquity to classify each case according to the criteria of the CPAK classification. Based on the aHKA result, 59.1% of the cases were varus (less than -2°), 32.7% were neutral (0° ± 2°), and 8.2% were valgus (greater than +2°). Based on the JLO result, 56.7% of the cases had a distal apex (less than 177°), 39.9% had a neutral apex (180° ± 3°), and 3.4% had a proximal apex (greater than 183°). The most common CPAK distribution in our Spanish southeast osteoarthritic population was type I (30.7%), followed by type IV (25.9%), type II (21%), type V (11.2%), type III (5%), type VI (2.8%), type VII (2.4%), type VIII (0.6%), and type IX (0.4%). We described the distribution according to the CPAK classification in a sample of the osteoarthritic population from southeastern Spain. In our sample, more than 75% of the patients were classified as type I, II, and IV.
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http://dx.doi.org/10.3390/medicina60101612 | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Department of Orthopaedics, First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Osteoarthritis is a prevalent joint disease in the aging population. The hallmark of osteoarthritis is the degeneration of the joint cartilage, characterized by changes in chondrocytes including mitochondrial dysfunction. However, the precise mechanisms of how this affects chondrocyte homeostasis and whether such processes can be explored as therapeutic targets for osteoarthritis remain unclear.
View Article and Find Full Text PDFCureus
June 2025
Orthopaedic Surgery, Shri B M Patil Medical College Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND.
Background Osteoarthritis (OA) of the knee is a leading cause of disability among the elderly population, characterized by chronic pain and functional impairment. When conservative treatments fail to provide relief, total knee replacement (TKR) emerges as the gold standard surgical intervention. The effectiveness of TKR depends on appropriate patient selection, surgical technique, and structured post-operative rehabilitation.
View Article and Find Full Text PDFArthritis Rheumatol
July 2025
Department of Joint Surgery, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Objective: This study aimed to investigate alterations in the spatial distribution of urate crystals in the osteoarthritic synovium of patients with different levels of serum uric acid (SUA). Additionally, we examined the association between SUA levels and severity of synovitis and pain in anteromedial osteoarthritis (AMOA) of the knee.
Methods: Patients who underwent knee arthroplasty due to AMOA were prospectively enrolled.
Microb Pathog
October 2025
Department of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, 214122, Jiangsu, China; Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, Jiangsu, China; School of Bioengineering, Jiangnan University, Wuxi, 214122, Jiangsu, China; School of Environment and Civil Engineering, Jia
Objective: Although obesity is recognized as a mechanical driver of osteoarthritis (OA), emerging evidence suggests gut microbiota independently contributes to OA pathogenesis. OA develops even in individuals without obesity, yet the distinct mechanistic roles of gut microbiota in OA progression among hosts with and without obesity remain uncharacterized. OA can develop in individuals without obesity, yet the distinct roles of gut microbiota in OA progression among those with and without obesity remain unclear.
View Article and Find Full Text PDFSci Adv
July 2025
Department of Stem Cells and Regenerative Medicine, Beijing Institute of Radiation Medicine, Road Taiping 27, Beijing 100850, P.R. China.
Osteoarthritis (OA) is a challenging degenerative joint disease with limited treatment options. Subchondral bone plays a critical role in maintaining joint homeostasis and influencing OA progression. Here, we investigated the role of senescence in mesenchyme-derived stem/progenitor cells (MDSPCs) during OA progression, aiming to identify potential therapeutic targets.
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