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: This study aimed to investigate the association between insulin resistance, as measured by the triglyceride-glucose index (TyG index), and hearing impairment in middle-aged women in Korea. : This cross-sectional survey utilized data from the Korea National Health and Nutrition Examination Survey (KNHANES) IV (2007-2009), specifically from the period after July 21, 2009, when hearing test results became available, and from the KNHANES V (2010-2012). This study was conducted on 5416 women aged 40 to 69 who had completed both the health examination survey and audiometric tests, excluding those with missing data on menopausal status and the use of hormone replacement therapy. : In the study group, the prevalence of high-frequency hearing loss according to the TyG index was significantly higher in the mild hearing loss group (OR = 1.29; 95% CI: 1.12, 1.49, < 0.001) and the moderate hearing loss group (OR = 1.27; 95% CI: 1.09, 1.48, = 0.002). Conversely, the prevalence of low-frequency hearing loss did not show a significant difference in either the mild hearing loss group (OR = 1.17; 95% CI: 0.99, 1.37, = 0.065) and the moderate hearing loss group (OR = 1.13; 95% CI: 0.94, 1.35, = 0.199) : Since diabetes can induce hearing impairment in women, it is recommended that women with a high TyG index undergo early hearing tests.
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http://dx.doi.org/10.3390/medicina60101596 | DOI Listing |
Am J Ind Med
September 2025
National Institute for Occupational Safety and Health, Division of Field Studies and Engineering, Cincinnati, Ohio, USA.
Background: Workers in industry settings are often exposed to complex noise, which poses a greater risk to hearing loss than continuous noise at equivalent energy levels. Previous studies have identified kurtosis as an essential metric for evaluating complex noise-induced hearing loss (NIHL). This study aimed to characterize the distribution of workers exposed to complex noise, examine the associations between kurtosis and changes in hearing thresholds at various frequencies, and explore kurtosis's role in estimating NIHL and its integration into occupational hearing loss prevention programs.
View Article and Find Full Text PDFNeurosci Bull
September 2025
Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, China.
The neurological manifestations of SHORT syndrome include intrauterine growth restriction, microcephaly, intellectual disability, hearing loss, and speech delay. SHORT syndrome is generally believed to be caused by PIK3R1 gene mutations and impaired PI3K-AKT activation. Recently, a clinical case report described a SHORT syndrome with a novel mutant in PRKCE gene encoding protein kinase Cε (PKCε).
View Article and Find Full Text PDFBehav Brain Res
September 2025
School of Human Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Tinnitus, the auditory perception of sound without an external environmental stimulus, affects 15% of the human population and is associated with hearing loss. Interestingly, anxiety may be a significant risk factor in tinnitus pathophysiology potentially due to underlying common neural circuits of the auditory and limbic systems. The current study aimed to investigate the effects of stress-induced anxiety on tinnitus development in a rat model.
View Article and Find Full Text PDFJ Diabetes Complications
August 2025
Vrije Universiteit Brussel, Bd de la Plaine 2, 1050 Ixelles, Belgium; KidZ Health Castle, Universiteit Ziekenhuis Brussel, Av du Laerbeek 101, 1090 Jette, Belgium. Electronic address:
Aims: Our review aimed to determine the prevalence of - and factors associated with - hearing loss, oral and olfactory disease, frozen shoulder, trigger finger, and hair loss in young adults with type 1 diabetes. These conditions were selected based on research team interests, existing literature, and group discussion.
Methods: We conducted a quantitative narrative review using a systematic process to identify cohort and cross-sectional studies involving young adults with type 1 diabetes (mean age 18-30 years).
Cancer Med
September 2025
Department of Medicine, University of Chicago, Chicago, Illinois, USA.
Background: Cisplatin is a commonly used chemotherapeutic across numerous cancer types that can cause neurotoxicities in patients, including peripheral sensory neuropathy, tinnitus, hearing loss, and vertigo.
Objective: We aimed to evaluate, for the first time, how genetic ancestry impacts cisplatin-induced neurotoxicities and if disparities are related to population differences in allele frequency.
Methods: In a cohort of cisplatin-treated testicular cancer survivors, relationships between genetic ancestry and neurotoxicities, medications, and lifestyle factors were assessed using logistic regression and Kruskal-Wallis tests and multiple pairwise comparisons using the Wilcoxon rank-sum test (Benjamini-Hochberg adjustment).