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http://dx.doi.org/10.1016/j.ejim.2024.10.013 | DOI Listing |
Macromol Biosci
September 2025
Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Conventional gelatin's gel-to-sol transition upon heating restricts its utility in biomedical applications that benefit from a gel state at physiological temperatures such as Pluronic F127 and poly(NIPAAm). Herein, we present "rev-Gelatin", a gelatin engineered with reverse thermo-responsive properties that undergoes a sol-to-gel transition as temperature rises from ambient to body temperature. Inspired by the phase dynamics of common materials like candy and ice cubes, whose surfaces soften or partially melt under warming, facilitating inter-object adhesion- rev-Gelatin leverages this concept to achieve fluidity at room temperature for easy injectability.
View Article and Find Full Text PDFJ Crohns Colitis
September 2025
Université de Paris, INSERM U1342, Institut de Recherche Saint-Louis, Paris, France.
Background And Aims: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), remain heterogeneous disorders with variable response to biologics. Post-operative recurrence in CD is common despite surgery and prophylactic biotherapies. Understanding the inflammatory mediators associated with recurrence and treatment response could pave the way for personalized strategies.
View Article and Find Full Text PDFJ Ultrasound Med
September 2025
Department of Clinical Analysis, Federal University of Santa Catarina (UFSC), Florianópolis, Brazil.
Objectives: To evaluate the performance of artificial intelligence (AI)-based models in predicting elevated neonatal insulin levels through fetal hepatic echotexture analysis.
Methods: This diagnostic accuracy study analyzed ultrasound images of fetal livers from pregnancies between 37 and 42 weeks, including cases with and without gestational diabetes mellitus (GDM). Images were stored in Digital Imaging and Communications in Medicine (DICOM) format, annotated by experts, and converted to segmented masks after quality checks.
Cell Mol Biol (Noisy-le-grand)
September 2025
Department of Health Sciences, University of York, York, U.K..
Dyslipidemia is considered a crucial risk factor for high risk of atherosclerosis and cardiovascular diseases. Cumin and coriander seeds are well-known flavoring agents that contain nutraceutical properties and appear to have beneficial health effects. A study was therefore conducted to investigate the effects of cumin and coriander seeds on body weight, abdominal fat and lipid profile in rats.
View Article and Find Full Text PDFClin Hemorheol Microcirc
September 2025
Department of Internal Medicine, Sultan Abdülhamid Han Research & Training Hospital, University of Health Sciences, Istanbul, Turkey.
ObjectivesThis study investigated haemorheological alterations in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).MethodsA total of 136 individuals were enrolled, comprising 52 healthy controls, 51 RA patients, and 33 SLE patients. Blood samples were collected at the University of Health Sciences Sultan Abdulhamid Han Training and Research Hospital in Istanbul, Türkiye.
View Article and Find Full Text PDF