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Ensuring the reliability of open-world intelligent systems heavily relies on effective out-of-distribution (OOD) detection. Despite notable successes in existing OOD detection methods, their performance in scenarios with limited training samples is still suboptimal. Therefore, we first construct a comprehensive few-shot OOD detection benchmark in this paper. Remarkably, our investigation reveals that Parameter-Efficient Fine-Tuning (PEFT) techniques, such as visual prompt tuning and visual adapter tuning, outperform traditional methods like fully fine-tuning and linear probing tuning in few-shot OOD detection. Considering that some valuable information from the pre-trained model, which is conducive to OOD detection, may be lost during the fine-tuning process, we reutilize features from the pre-trained models to mitigate this issue. Specifically, we first propose a training-free approach, termed uncertainty score ensemble (USE). This method integrates feature-matching scores to enhance existing OOD detection methods, significantly narrowing the gap between traditional fine-tuning and PEFT techniques. However, due to its training-free property, this method is unable to improve in-distribution accuracy. To this end, we further propose a method called Domain-Specific and General Knowledge Fusion (DSGF) to improve few-shot OOD detection performance and ID accuracy under different fine-tuning paradigms. Experiment results demonstrate that DSGF enhances few-shot OOD detection across different fine-tuning strategies, shot settings, and OOD detection methods. We believe our work can provide the research community with a novel path to leveraging large-scale visual pre-trained models for addressing FS-OOD detection. The code will be released.
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http://dx.doi.org/10.1109/TIP.2024.3468874 | DOI Listing |
Comput Methods Programs Biomed
September 2025
Eindhoven University of Technology, Department of Biomedical Engineering, Medical Image Analysis Group, Eindhoven, The Netherlands. Electronic address:
Background And Objective: Out-of-distribution (OOD) detection is crucial for safely deploying automated medical image analysis systems, as abnormal patterns in images could hamper their performance. However, OOD detection in medical imaging remains an open challenge. In this study, we aim to optimize a reconstruction-based autoencoder specifically for OOD detection.
View Article and Find Full Text PDFMed Image Anal
August 2025
School of Computer Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China; Shaanxi Provincial Key Laboratory of Big Data Knowledge Engineering, Xi'an Jiaotong University, Xi'an, 710049, China. Electronic address:
Modern Computational pathology (CPath) models aim to alleviate the burden on pathologists. However, once deployed, these models may generate unreliable predictions when encountering data types not seen during training, potentially causing a trust crisis within the computational pathology community. Out-of-distribution (OOD) detection, acting as a safety measure before model deployment, demonstrates significant promise in ensuring the reliable use of models in real clinical application.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
August 2025
In real-world scenarios, distribution shifts give rise to the importance of two problems: out-of-distribution (OoD) generalization, which focuses on models' generalization ability against covariate shifts (i.e., the changes of environments), and OoD detection, which aims to be aware of semantic shifts (i.
View Article and Find Full Text PDFJ Biomed Inform
September 2025
University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:
Objective: In biomedical research, knowledge about the relationships between entities, including genes, proteins, and drugs, is vital for elucidating complex biological processes and intracellular pathway mechanisms. While natural language processing (NLP) methods have shown great success in biomedical relation extraction (RE), extracted relations often lack contextual information such as cell type, cell line, and intracellular location. Previous studies treated this problem as a post hoc context-relation association task, limited by the absence of a golden standard corpus and prone to error propagation.
View Article and Find Full Text PDFIEEE Trans Pattern Anal Mach Intell
July 2025
In general, learning plentiful knowledge corresponding to known objects is an important ability for humans. The unknown objects could be assumed to depart from the familiar knowledge. Inspired by this idea, we explore leveraging the extracted knowledge to reason a set of unknown concepts.
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