360° CZT-SPECT/CT cameras: Tc- and Lu-phantom-based evaluation under clinical conditions.

Purpose: For the first time, three currently available 360° CZT-SPECT/CT cameras were compared under clinical conditions using phantom-based measurements.

Methods: A Tc- and a Lu-customized NEMA IEC body phantom were imaged with three different cameras, StarGuide (GE Healthcare), VERITON-CT versions 200 (V200) and 400 (V400) (Spectrum Dynamics Medical) under the same clinical conditions. Energy resolution and volumetric sensitivity were evaluated from energy spectra. Vendors provided the best reconstruction parameters dedicated to visualization and/or quantification, based on their respective software developments. For both Tc- and Lu-phantoms, noise level, quantification accuracy, and recovery coefficient (RC) were performed with 3DSlicer. Image quality metrics from an approach called "task-based" were computed with iQMetrix-CT on Tc visual reconstructions to assess, through spatial frequencies, noise texture in the background (NPS) and contrast restitution of a hot insert (TTF). Spatial resolution indices were calculated from frequencies corresponding to TTF and TTF.

Results: Despite the higher sensitivity of VERITON cameras and the enhanced energy resolution of the V400 (3.2% at 140 keV, 5.2% at 113 keV, and 3.6% at 208 keV), StarGuide presents comparable image quality. This highlights the need to differentiate sensitivity from count quality, which is influenced by hardware design (collimator, detector block) and conditions image quality as well as the reconstruction process (algorithms, scatter correction, noise regulation). For Tc imaging, the quantitative image optimization approach based on RC for StarGuide versus RC for V200 and V400 systems (RC/RC: 0.9/1.8; 0.5/0.9; 0.5/0.9 respectively-Ø37 mm). SR showed nearly equivalent spatial resolution performances across the different reconstructed images. For Lu imaging, the 113 keV imaging of the V200 and V400 systems demonstrated strong performances in both image quality and quantification, while StarGuide and V400 systems offer even better potential due to their ability to exploit signals from both the 113 and 208 keV peaks. Lu quantification was optimized according to RC for all cameras and reconstructions (1.07 ± 0.09-Ø37 mm).

Conclusions: The three cameras have equivalent potential for Tc imaging, while StarGuide and V400 have demonstrated higher potential for Lu. Dedicated visual or quantitative reconstructions offer better specific performances compared to the unified visual/quantitative reconstruction. The task-based approach appears to be promising for in-depth comparison of images in the context of system characterization/comparison and protocol optimization.