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http://dx.doi.org/10.3341/kjo.2024.0072 | DOI Listing |
J Appl Toxicol
September 2025
Research Centre for Veterinary Toxicology (CEPTOX) - Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, Pirassununga, SP, Brazil.
L-mimosine is a non-protein amino acid primarily found in the Mimosoideae subfamily, with high concentrations in Leucaena leucocephala and Mimosa pudica. These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L-mimosine have been extensively studied in ruminants, its impact on monogastric species remains unexplored.
View Article and Find Full Text PDFJ Toxicol
August 2025
Department of Periodontology and Oral Implantology, Kathmandu Medical College Public Limited, Kathmandu 44600, Nepal.
Herbal formulations with antimicrobial and anti-inflammatory properties are commonly used in traditional medicine for oral hygiene. Despite growing popularity, little or no research exists on the safety profile of these products to confirm their long-term safety. An ayurvedic dentifrice formulation was analyzed in Wistar albino rats for acute and subacute oral toxicity, with emphasis on the toxic effects of the product on physiological, hematological, biochemical, and histopathological parameters.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
Shaanxi University of Chinese Medicine, Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, 712083, Xianyang, PR China. Electronic address:
Ethnopharmacological Relevance: Yinaoxin granules (YNX) is a widely used Chinese herbal preparation composed of six medicinal herbs. YNX has been shown to effectively mitigate both headaches and dizziness. However, systematic investigations into its chemical basis and safety profile remain limited.
View Article and Find Full Text PDFPart Fibre Toxicol
September 2025
Department of Pharmaceutical Sciences, 1 University of New Mexico College of Pharmacy, MSC09 5360, Albuquerque, NM, 87131-0001, USA.
Background: Wildland fires in the United States have increased in frequency and scale over the past 30 years exposing millions of people to hazardous air pollutants. Among others, aging individuals are particularly vulnerable to the effects of wildfire smoke. In this study, we assessed the neurobiological impacts of wood smoke (WS) on aged mice and the potential of anti-aging therapeutics to mitigate these impacts.
View Article and Find Full Text PDFTrop Med Health
August 2025
Department of Plant Science, Microbiology and Biotechnology, School of Biosciences, College of Natural Sciences, Makerere University, P. O. Box 7062, Kampala, Uganda.
Background: Khaya anthotheca (Meliaceae) is a medicinal plant with a wide range of therapeutic properties attributable mainly to the diverse limonoids it contains. Different parts of the plant are used in traditional health care for treatment of various diseases including candidiasis. However, inadequate information on its safety prompted this particular study.
View Article and Find Full Text PDF