Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Oxidative stress generated during aging largely affects erythrocytes. Antioxidative therapies such as polyphenols and flavonoids face limitations like low bioavailability and reduced efficiency. Cerium oxide nanoparticles (CeONPs) can behave as antioxidative enzymes and thus have better efficiency. Additionally, biopolymer coatings such as polyethylene glycol and polysaccharides such as dextran enhance the biocompatibility of these NPs. Therefore, we synthesized and characterized bare, polyethylene glycol, dextran-coated CeONPs and examined their hemocompatibility and protective effect against age-induced oxidative stress in erythrocytes. Erythrocytes were obtained from 5 ml of fresh blood drawn from 52 healthy individuals aged 20-85 years with their consent. CeONPs were found to be protective against age-induced oxidative damage in erythrocytes such as reduced levels of antioxidants and increased levels of oxidative species. Pretreatment with NPs protected the morphology and membrane integrity of erythrocytes. Among the NPs investigated, dextran-coated CeONPs emerged as the most effective, providing a reassuring sign of progress in anti-aging research. Therefore, Dex-CeONPs can be used as potential antioxidant therapeutics against age-induced oxidative stress.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijbiomac.2024.136700 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dual function of itaconic acid from against .
Plant Dis
September 2025
Shenyang Agricultural University, College of Plant Protection, Nematology Institute of Northern China, Shenyang, China;
Root-knot nematodes (Meloidogyne spp.) cause catastrophic yield losses in global agriculture. This study identified itaconic acid (IA), through comparative metabolomic analysis (the study of small molecules in biological systems), as a key virulence-related metabolite produced by the fungus Trichoderma citrinoviride Snef1910.
View Article and Find Full Text PDFL-Carnitine Modulates Oocyte Development and Cumulus Expansion in Tropical Ruminants: Experimental and Bioinformatics Insights.
Anim Sci J
January 2025
Department of Animal Science, Bangladesh Agricultural University, Mymensingh, Bangladesh.
This study investigates the effects of L-carnitine on nuclear maturation and fertilization in cattle and goat oocytes. Ovaries were collected from females with poor reproductive efficiency in the tropical climate, and cumulus-oocyte complexes (COCs) were retrieved from large antral follicles. COCs were cultured with varying concentrations of L-carnitine (0, 0.
View Article and Find Full Text PDFCaffeine mitigates ROS accumulation and attenuates motor neuron degeneration in the wobbler mouse model of amyotrophic lateral sclerosis.
Cell Commun Signal
September 2025
Department of Cytology, Institute of Anatomy, Medical Faculty, Ruhr-University Bochum, Universitätsstr. 150, Building MA 5/52, Bochum, 44801, Germany.
Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by oxidative stress and progressive motor neuron degeneration. This study evaluates the potential neuroprotective effects of caffeine in the Wobbler mouse, an established model of ALS.
Methods: Wobbler mice received caffeine supplementation (60 mg/kg/day) via drinking water, and key parameters, including muscle strength, NAD metabolism, oxidative stress, and motor neuron morphology, were assessed at critical disease stages.
Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours.
Nature
September 2025
Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Monocyte-derived macrophages (mo-macs) often drive immunosuppression in the tumour microenvironment (TME) and tumour-enhanced myelopoiesis in the bone marrow fuels these populations. Here we performed paired transcriptome and chromatin accessibility analysis over the continuum of myeloid progenitors, circulating monocytes and tumour-infiltrating mo-macs in mice and in patients with lung cancer to identify myeloid progenitor programs that fuel pro-tumorigenic mo-macs. We show that lung tumours prime accessibility for Nfe2l2 (NRF2) in bone marrow myeloid progenitors as a cytoprotective response to oxidative stress, enhancing myelopoiesis while dampening interferon response and promoting immunosuppression.
View Article and Find Full Text PDFABCA7 variants impact phosphatidylcholine and mitochondria in neurons.
Nature
September 2025
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
Loss-of-function variants in the lipid transporter ABCA7 substantially increase the risk of Alzheimer's disease, yet how they impact cellular states to drive disease remains unclear. Here, using single-nucleus RNA-sequencing analysis of human brain samples, we identified widespread gene expression changes across multiple neural cell types associated with rare ABCA7 loss-of-function variants. Excitatory neurons, which expressed the highest levels of ABCA7, showed disrupted lipid metabolism, mitochondrial function, DNA repair and synaptic signalling pathways.
View Article and Find Full Text PDF