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http://dx.doi.org/10.1136/bmjebm-2024-112896 | DOI Listing |
Crit Rev Ther Drug Carrier Syst
January 2025
The emergence of messenger ribonucleic acid (mRNA) vaccines as an alternative platform to traditional vaccines has been accompanied by advances in nanobiotechnology, which have improved the stability and delivery of these vaccines through novel nanoparticles (NPs). Specifically, the development of NPs for mRNA delivery has facilitated the loading, protection and release of mRNA in the biological microenvironment, leading to the stimulation of mRNA translation for effective intervention strategies. Intriguingly, two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), have been permitted for emergency usage authorization to prevent COVID-19 infection by USFDA.
View Article and Find Full Text PDFCrit Rev Ther Drug Carrier Syst
January 2025
Department of Pharmacology, PSG College of Pharmacy, Coimbatore 641004, Tamil Nadu, India.
Treating neurological disorders is challenging due to the blood-brain barrier (BBB), which limits therapeutic agents, including proteins and peptides, from entering the central nervous system. Despite their potential, the BBB's selective permeability is a significant obstacle. This review explores recent advancements in protein therapeutics for BBB-targeted delivery and highlights computational tools.
View Article and Find Full Text PDFNeural Netw
September 2025
Shanghai Maritime University, Shanghai, 201306, China. Electronic address:
Cross-modal hashing aims to leverage hashing functions to map multimodal data into a unified low-dimensional space, realizing efficient cross-modal retrieval. In particular, unsupervised cross-modal hashing methods attract significant attention for not needing external label information. However, in the field of unsupervised cross-modal hashing, there are several pressing issues to address: (1) how to facilitate semantic alignment between modalities, and (2) how to effectively capture the intrinsic relationships between data, thereby constructing a more reliable affinity matrix to assist in the learning of hash codes.
View Article and Find Full Text PDFJ Med Chem
September 2025
State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Discovery o
Aberrant activation of fibroblast growth factor receptors (FGFRs) plays a critical role in tumorigenesis across multiple cancer types, driving the development of various FGFR inhibitors. Despite clinical advances, therapeutic efficacy remains limited by the emergence of drug resistance, primarily mediated by gatekeeper mutations in FGFRs. To overcome this challenge, we designed and synthesized a novel series of 7-(1-methyl-1-indole-3-yl)-5-pyrrolo[2,3-]pyrazine derivatives as covalent pan-FGFR inhibitors targeting both wild-type and gatekeeper mutants.
View Article and Find Full Text PDFInorg Chem
September 2025
Institutes of Physical Science and Information Technology, Key Laboratory of Structure and Functional Regulation of Hybrid Materials (Anhui University), Ministry of Education, Hefei 230601, P. R. China.
Precisely structured nanoclusters provide ideal platforms for elucidating structural evolution and structure-activity relationships. However, mechanistic understanding of dynamic core-shell rearrangements has long been impeded by the elusive nature of intermediates during transformation processes. Here, we show that ligand engineering-driven asymmetric thiolate exchange enables atomic-level visualization of structural evolution, thereby overcoming the long-standing challenge of intermediate capture.
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