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Article Abstract
Two new caffeoyl triterpenes, -lupacosmeol (1) alone and in mixture with -lupacosmeol (2), and two known compounds, 16β-hydroxy-3β--caffeoyl-olean-12-ene (3) and 16β-hydroxy-3β-p-coumaroyl-lup-20(29)-ene (4), were isolated from the roots of . The structures were chemically characterised using 1D and 2D NMR, IR spectroscopy, and HRESIMS techniques. Cytotoxicity was evaluated against three different cancer cell lines (MCF-7, HCT-116, SK-MEL-28). Only mixture 2 showed activity against all strains tested, with more pronounced ability to inhibit SK-MEL-28 growth (IC: 25.45 µg/mL). Molecular docking studies suggested that the cytotoxic activity of 2 was strongly attributed to interactions between -lupacosmeol and -lupacosmeol, which are present in mixtures used to treat melanoma and exhibit activities towards different molecular targets of importance.
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| http://dx.doi.org/10.1080/14786419.2024.2415430 | DOI Listing |
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Article Synopsis
- Two new caffeoyl triterpenes, -lupacosmeol (1) and a mixture of -lupacosmeol (2), were isolated from plant roots along with two known compounds.
- Their structures were analyzed using advanced chemical techniques like 1D and 2D NMR, IR spectroscopy, and HRESIMS.
- The mixture 2 was found to be cytotoxic against multiple cancer cell lines, especially inhibiting the growth of SK-MEL-28, with its activity linked to the interaction between the two triterpenes in the mixture.
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