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Coronary CT angiography (CCTA) and fractional flow reserve with CCTA (FFRCT) have been endorsed by the ACC/AHA Chest Pain guidelines to streamline the diagnosis of coronary artery disease (CAD), but there is still a significant lack of adherence. In our study of 673 stable chest patients without known CAD from 5 European countries, we found that CCTA is the most common noninvasive diagnostic test, but nearly 40 % of them still underwent upfront CAD. Additionally, there was no temporal improvement trend, and the integration of FFRCT is low. We highlighted the urgent need to improve diagnostic processes and update reimbursement policies.
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http://dx.doi.org/10.1016/j.jcct.2024.10.002 | DOI Listing |
Lancet Infect Dis
September 2025
The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Based on results from preclinical and clinical studies, a five-drug combination of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine was identified with treatment shortening potential for drug-susceptible tuberculosis; the Clo-Fast trial aimed to determine the efficacy and safety of this regimen. We compared 3 months of isoniazid, rifapentine, pyrazinamide, ethambutol, and clofazimine, administered with a clofazimine loading dose, to the standard 6 month regimen of isoniazid, rifampicin, pyrazinamide, and ethambutol in drug-susceptible tuberculosis.
Methods: Clo-Fast was a phase 2c open-label trial recruiting participants at six sites in five countries.
JACC Case Rep
September 2025
Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Cardiac Surgery, St Michael's Hospital of Unity Health Toronto, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada; Department of Surgery, University of Toronto, Toronto, Ontario, Canada; Department of P
Background: Rupture of a root and ascending aortic aneurysm is a rare, life-threatening condition requiring prompt recognition and surgical intervention. Elevated lipoprotein(a) levels have been implicated in vascular pathology but are less studied in thoracic aneurysms.
Case Summary: A 61-year-old man who presented with severe dyspnea and chest tightness was found to have a 7.
Ulus Travma Acil Cerrahi Derg
September 2025
General Surgery Clinic, SBU Gulhane Hospital, İstanbul-Türkiye.
Background: This study aims to retrospectively evaluate treatment approaches and clinical outcomes in patients with penetrating abdominal trauma caused by gunshot injuries-one of the most complex and controversial areas in trauma surgery.
Methods: A total of 101 patients diagnosed and treated for penetrating abdominal trauma due to gunshot injuries between 2015 and 2025 were included in the study. Demographic data (age and sex); vital signs at admission to the emergency department (blood pressure, pulse, respiratory rate, body temperature); level of consciousness (Glasgow Coma Scale); hemodynamic status (stability/instability, need for fluid or inotropic support); intra-abdominal (liver, spleen, small intestine, colon, etc.
J Emerg Med
July 2025
Department of Emergency Medicine, All India Institute of Medical Sciences, New Delhi, India.
Unilateral pulmonary edema (UPE) is an uncommon clinical presentation, accounting for approximately 2% of cardiogenic pulmonary edema cases, and often mimics pulmonary infections, leading to diagnostic delays. We report the case of a 51-year-old woman with rheumatic heart disease who presented with progressive dyspnea and pedal edema. Clinical findings suggested pulmonary edema, but chest radiography revealed predominantly left-sided congestion.
View Article and Find Full Text PDFMed Int (Lond)
August 2025
Department of Scientific Affairs, Smart Health Tower, Sulaymaniyah 46001, Iraq.
Giant teratomas with bilateral mediastinal extension are rare. The present case report highlights the challenging resection of a giant anterior mediastinal cystic teratoma extending bilaterally using video-assisted thoracoscopic surgery (VATS), rendering it one of the largest mediastinal teratomas managed with VATS in the current literature. A 47-year-old woman presented with a 1-year history of central chest pain.
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