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Although previously considered rare, spontaneous coronary artery dissection (SCAD) is increasingly recognized as an important cause of myocardial infarction in young women. We present three unique cases of SCAD: A 46-year-old woman with a history of trigeminal neuralgia and anxiety presenting elevated troponin-I and chest pain. A 36-year-old woman with recent miscarriage presenting with diffuse T wave inversions and elevated troponin-I. A 58-year-old man with a recent COVID-19 infection presenting with diffuse ST elevations. SCAD is associated with many risk factors. Conservative management is preferred due to spontaneous healing of vessels compared to PCI-driven management of atherosclerotic acute coronary syndrome.
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http://dx.doi.org/10.55729/2000-9666.1355 | DOI Listing |
Heart Lung
September 2025
The First School of Clinical Medicine, Southern Medical University, Guangzhou 510515, China; Department of Critical Care Medicine, General Hospital of Southern Theatre Command of Chinese PLA, Guangzhou 510010, China; Guangdong Branch Center, National Clinical Research Center for Geriatric Diseases,
Background: Standardized spontaneous breathing trial (SBT) techniques for patients with heart failure (HF) are lacking.
Objectives: To compare the efficacy of low-level pressure-supported ventilation (PSV) and T-piece SBT techniques in patients with HF.
Methods: This single-center, prospective, open-label, randomized controlled study enrolled mechanically ventilated adults with stage B HF (Nov 2022-Apr 2024).
JACC Case Rep
September 2025
Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
Background: The Wenckebach phenomenon of atrioventricular conduction is deemed a physiological response of the atrioventricular node to a high atrial rate. However, the reverse Wenckebach phenomenon is under-recognized.
Case Summary: We report an instance of reverse Wenckebach phenomenon developing into complete heart block in a 33-year-old man who experienced syncope after surgical repair of prolapsed bicuspid aortic valves.
Am J Cardiol
September 2025
Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA, 85054; Department of Clinical Genomics, Mayo Clinic, Phoenix, AZ, USA.
Background/objective: Spontaneous coronary artery dissection (SCAD) is increasingly recognized as a cause of acute coronary syndrome and has been associated with extracoronary arteriopathies, such as fibromuscular dysplasia (FMD), aneurysms, and dissections across other vascular beds. However, these associations remain understudied in the literature. This study aims to characterize the prevalence and distribution of extracoronary arteriopathies in a large cohort of SCAD patients.
View Article and Find Full Text PDFNeurocrit Care
September 2025
Michael E. DeBakey VA Medical Center, Baylor College of Medicine, Houston, TX, USA.
Background: Recent American Heart Association guidelines have relied on post hoc subgroup analyses to identify summary blood pressure measures for targets in early management of acute intracerebral hemorrhage. To our knowledge, measurement error has not been considered when determining the impact of these summary measures. Our objective was to determine whether statistically significant differences in three systolic blood pressure (SBP) measures (achieved SBP, SBP variability, and magnitude of SBP reduction) in patients with intracerebral hemorrhage from the antihypertensive treatment of acute cerebral hemorrhage II (ATACH-2) randomized clinical trial are clinically meaningful by comparing them to a minimally detectable difference (MDD) of 10 mm Hg.
View Article and Find Full Text PDFJ Appl Physiol (1985)
September 2025
Cardiovascular Research Laboratory, Spaulding Hospital Cambridge, Cambridge, MA.
Assessment of sympathetic transduction into its effects on the cardiovascular system is of great interest in human research. Analysis of sympathetic transduction has been divided into neurovascular and neurohemodynamic, highlighting the sympathetic effect on either regional vascular or systemic pressure responses. This study investigates whether indices of neurovascular transduction are reflected in parallel neurohemodynamic transduction during normoxia and hypoxia, with and without accounting for the confounds of prevailing tachypnea and tachycardia.
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