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Suturing techniques for wound closure in spine surgeries play a critical role in patient outcomes, including wound healing, reintervention, and risk of complications. Barbed sutures, characterized by their self-anchoring properties, have emerged as a potential alternative to conventional sutures in various surgical disciplines. While previous studies have underscored their efficacy and safety in spine surgeries, no meta-analysis has been conducted. Therefore, we are undertaking this study. Following the PRISMA guidelines, we conducted a literature search on electronic databases to obtain the relevant studies until May 5, 2024. Our primary outcomes were operative time, wound closure time, and postoperative wound complications like seroma or hematoma formation and wound infection. The secondary outcomes were the length of hospital stay, reintervention rates, and costs. Data was pooled using a random effects model. We included seven eligible studies with a total of 8645 patients. Our meta-analysis showed that barbed sutures had shorter operative time and wound closure time compared to conventional sutures (MD -20.13 min, 95% CI [-28.47, -11.78], P < 0.001) and (MD -16.36 min, 95% CI [-20.9, -11.82], P < 0.001), respectively. Both suturing techniques showed comparable results in terms of overall postoperative wound complications (RR 0.83, 95% CI [0.60, 1.14], P = 0.25), postoperative infections (RR 0.59, 95% CI [0.33, 1.06], P = 0.08), length of hospital stay (MD -0.26 day, 95% CI [-0.75, 0.22], P = 0.28), rates of reintervention between the two groups (RR 0.99, 95% CI [0.48, 2.05], P = 0.98). Barbed sutures in spine surgeries are associated with significantly shortened wound closure and operative times. However, high-quality RCT's with long-term follow-up and cost-effectiveness assessment are required to support the evidence.
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http://dx.doi.org/10.1007/s10143-024-02909-9 | DOI Listing |
Naturwissenschaften
September 2025
Department of Biomedical Engineering, Sri Sivasubramaniya Nadar College of Engineering, Kalavakkam, 603110, Tamil Nadu, India.
Wounds with extensive tissue damage are highly susceptible for microbial infections delaying the process of wound healing. Currently, biomaterials with therapeutic molecules emerged as key players in wound repairing. This work developed a novel collagen-based hydrogel loaded with allicin and silver nanoparticles.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Amur Regional Clinical Hospital, Blagoveshchensk, Russia.
The authors present treatment of patients with spinal injury complicated by extensive multiple pressure sores. A comprehensive preoperative management was followed by staged surgical treatment. Advisability of deep bedsore closure with full-layer flaps and staged interventions was justified.
View Article and Find Full Text PDFTidsskr Nor Laegeforen
September 2025
Nevrokirurgisk avdeling, Oslo universitetssykehus, Rikshospitalet, og, Pediatrisk nevrokirurgisk forskningsgruppe, Universitetet i Oslo.
Background: Closure of soft tissue defects following surgical repair of neonatal myelomeningocele requires prompt and well-justified decisions regarding the reconstruction method if the defects are to be closed within the first two days of life. For larger defects, flap reconstruction is often necessary. The aim of the study was to examine reconstruction methods for closing soft tissue defects following surgery for myelomeningocele, as well as complications and the need for reoperation.
View Article and Find Full Text PDFJ Ethnopharmacol
September 2025
Department of Bachelor's Degree Program for Indigenous Peoples in Senior Health and Care Management, National Taitung University, Taitung, 950, Taiwan; Master Program in Biomedical Science, National Taitung University, Taitung, 950, Taiwan; Elderly Industry Sustainable Low Carbon Research Center, Na
Ethnopharmacological Relevance: Ocimum gratissimum L. commonly known as basil, is an herb-like plant frequently mentioned in ethnopharmacological studies due to its widespread availability in local communities and its widespread use in treating inflammatory conditions. In a previous study, we demonstrated that aqueous extracts of Ocimum gratissimum (OGE), which are rich in plant polyphenols such as caffeic acid and isoflavones, can protect skin cells from UVC-induced inflammation and damage in migration and proliferation.
View Article and Find Full Text PDFChem Biodivers
September 2025
Department of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Türkiye.
The biological activities and phytochemical composition of Alchemilla daghestanica and Alchemilla minusculiflora were investigated for the first time. Methanol extracts from the aerial and root parts of both species were assessed. The total phenolic content was highest in the root extracts.
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