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Accurately representing changes in mental states over time is crucial for understanding their complex dynamics. However, there is little methodological research on the validity and reliability of human-produced continuous-time annotation of these states. We present a psychometric perspective on valid and reliable construct assessment, examine the robustness of interval-scale (e.g., values between zero and one) continuous-time annotation, and identify three major threats to validity and reliability in current approaches. We then propose a novel ground truth generation pipeline that combines emerging techniques for improving validity and robustness. We demonstrate its effectiveness in a case study involving crowd-sourced annotation of perceived violence in movies, where our pipeline achieves a .95 Spearman correlation in summarized ratings compared to a .15 baseline. These results suggest that highly accurate ground truth signals can be produced from continuous annotations using additional comparative annotation (e.g., a versus b) to correct structured errors, highlighting the need for a paradigm shift in robust construct measurement over time.
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http://dx.doi.org/10.3758/s13428-024-02503-3 | DOI Listing |
Bioinform Adv
September 2025
Data Science in Systems Biology, TUM School of Life Sciences, Technical University of Munich, Freising, 85354, Germany.
Summary: Cell-type deconvolution is widely applied to gene expression and DNA methylation data, but access to methods for the latter remains limited. We introduce , a new R package that simplifies access to DNA methylation-based deconvolution methods predominantly for blood data, and we additionally compare their estimates to those from gene expression and experimental ground truth data using a unique matched blood dataset.
Availability And Implementation: is available at https://github.
Sci Rep
September 2025
Center for Northeast Asian Studies, Tohoku University, 41 Kawauchi, Sendai Aoba-ku, Miyagi, 980-8576, Japan.
Petit-spot volcanism plays a critical role in the metasomatism of oceanic plates prior to subduction and in their recycling into the deep mantle. The extent of metasomatism depends on the number and volume of petit-spot volcanic edifices and intrusions, making precise identification of petit-spot volcanic fields essential. However, conventional methods based on seafloor topography and acoustic backscatter intensity alone have limitations in accurately delineating these features.
View Article and Find Full Text PDFRetina
September 2025
Department of Ophthalmology, Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, CH-3010.
Purpose: To evaluate inter-grader variability in posterior vitreous detachment (PVD) classification in patients with epiretinal membrane (ERM) and macular hole (MH) on spectral-domain optical coherence tomography (SD-OCT) and identify challenges in defining a reliable ground truth for artificial intelligence (AI)-based tools.
Methods: A total of 437 horizontal SD-OCT B-scans were retrospectively selected and independently annotated by six experienced ophthalmologists adopting four categories: 'full PVD', 'partial PVD', 'no PVD', and 'ungradable'. Inter-grader agreement was assessed using pairwise Cohen's kappa scores.
Abdom Radiol (NY)
September 2025
Research Centre for Optimal Health, School of Life Sciences, University of Westminster, London, UK.
Objectives: The escalating global incidence of obesity, cardiometabolic disease and sarcopenia necessitates reliable body composition measurement tools. MRI-based assessment is the gold standard, with utility in both clinical and drug trial settings. This study aims to validate a new automated volumetric MRI method by comparing with manual ground truth, prior volumetric measurements, and against a new method for semi-automated single-slice area measurements.
View Article and Find Full Text PDFAnal Chem
September 2025
State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist University, Hong Kong SAR 999077, China.
Mass spectrometry imaging (MSI) is a label-free technique that enables the visualization of the spatial distribution of thousands of ions within biosamples. Data denoising is the computational strategy aimed at enhancing the MSI data quality, providing an effective alternative to experimental methods. However, due to the complex noise pattern inherent in MSI data and the difficulty in obtaining ground truth from noise-free data, achieving reliable denoised images remains challenging.
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