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The United States has seen increasing trends of maternal mortality in recent years. Within this health crisis there are large disparities whereby underserved and minoritized populations are bearing a larger burden of maternal morbidity and mortality. While new interventions to improve maternal health are being developed, there are opportunities for greater integration of existing evidence-based interventions into routine practice, especially for underserved populations, including those residing in maternity care deserts. In fact, over 80 percent of maternal deaths are preventable with currently available interventions. To spur equitable implementation of existing interventions, the National Heart, Lung, and Blood Institute launched the Maternal-Health Community Implementation Program (MH-CIP) in 2021. In 2023, the National Institutes of Health's Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE) initiative partnered with the NHLBI to launch the IMPROVE Community Implementation Program (IMPROVE-CIP). By design, CIPs engage disproportionately impacted communities and partner with academic researchers to conduct implementation research. This commentary overviews the impetus for creating these programs, program goals, structure, and offers a high-level overview of the research currently supported. Lastly, the potential outcomes of these programs are contextualized within the landscape of maternal health initiatives in the United States.
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http://dx.doi.org/10.1186/s43058-024-00634-4 | DOI Listing |
J Urban Health
September 2025
Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.
Timely access to comprehensive , high-quality emergency obstetric and neonatal care can prevent maternal and neonatal mortality but remains challenging in Benin. We examine geographic accessibility to childbirth care (CBC) in Grand Nokoué, the largest conurbation in Benin. We gathered data on boundaries, health facilities, road network, elevation, land cover, relative wealth, urbanicity, and geo-traced travel speeds over 45 days during the rainy season.
View Article and Find Full Text PDFArch Gynecol Obstet
September 2025
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Objective: To investigate adverse pregnancy and delivery outcomes in women with GDMA1 during pregnancies conceived through fertility treatments.
Methods: This population-based retrospective cohort study examined adverse pregnancy and delivery outcomes in pregnancies affected by GDMA1 following fertility treatments compared to those conceived naturally. Women with GDMA1 who conceived via fertility treatments were classified as cases, while those who conceived naturally were designated as controls.
Khirurgiia (Mosk)
September 2025
Sevastopol City Hospital No. 5 - Center for Maternal and Child Health Protection, Sevastopol, Russia.
Objective: To analyze clinical data and predictors of mortality neonatal spontaneous gastric perforation (SGP).
Material And Methods: A two-center retrospective cohort study included neonates diagnosed with SGP between 1999 and 2023. This cohort was divided into survivors and dead neonates to identify prognostic factors of mortality.
Int J Health Care Qual Assur
September 2025
Department of Electrical and Computer Engineering, Graduate University of Advanced Technology, Kerman, Iran.
Purpose: Neonatal mortality is a significant global health issue, particularly in low- and middle-income countries. This study aims to identify and understand the factors contributing to high neonatal mortality rates in the cities of Kerman and Bam, Iran, to develop effective strategies for improvement.
Design/methodology/approach: We employed systems dynamics to develop Causal Loop Diagrams that capture qualitative interactions among determinants of neonatal mortality.
J Clin Pharmacol
September 2025
Department of Pharmacy, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Topiramate is increasingly used in the treatment of epilepsy during pregnancy. However, its plasma concentration evidently decreases during pregnancy, which may reduce its efficacy. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model of topiramate to simulate maternal and fetal pharmacokinetic changes across different trimesters and to propose dose adjustments.
View Article and Find Full Text PDF