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The aim of this study is to validate the FIDBv2 online procedure for adult age-at-death estimation using root dentine translucency (RDT) and periodontal retraction (PR) of single-rooted teeth in a worldwide sample. The sample includes 4810 teeth of 2559 individuals from 16 countries of America, Europe and Asia. Bias and inaccuracy between documented (DA) and estimated ages (EA) were calculated. Pearson and Intraclass Correlation Coefficients were computed to assess the strength of agreement between pairs of data, while Kolmogorov-Smirnov Z was used to evaluate the statistical significance of the differences. The percentages of correctly estimated cases within different age ranges were obtained to find trends in the reliability of the results. Most of the biases (-4.61-1.31 years) and inaccuracies (4.81-9.72 years) are low. The dispersion of EA increases with age and almost all the DA-EA correlations are above 0.75. DA-RDT and DA-PR correlations are positive, most of the former being high (0.74-0.91), and the latter being low (0.11-0.54). The highest percentages of correct estimations are identified for the ±7.5 and ±10 years ranges, and most comparisons of bias and inaccuracy between countries are non-significant. The high correlations between DA and EA suggest that the method is robust and reliable for a global application. Mean errors are low, with the best results found in the 30-69-year-old cohort. This research supports that the method is effective and accurate for age estimation in forensic contexts worldwide, thus reaffirming it is a generalizable procedure locally and internationally.
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http://dx.doi.org/10.1016/j.forsciint.2024.112230 | DOI Listing |
Neuropsychopharmacol Rep
September 2025
Department of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Controlling for confounding factors in postmortem brain studies of psychiatric disorders is crucial, particularly in gene expression analyses. Potential confounding factors include sex, age at death, medication history, agonal state, postmortem interval (PMI), tissue storage duration, tissue pH, and RNA integrity number (RIN). pH and RIN are considered particularly important in gene expression analysis because they accurately reflect mRNA quality.
View Article and Find Full Text PDFDiabetes Ther
September 2025
Diabetes Care Unit, Caen University Hospital, UNICAEN, 14033, Caen Cedex 09, France.
Introduction: Diabetes represents an increasing public health challenge in France, yet national data distinguishing type 1 from type 2 diabetes and insulin use remain limited. This study aimed to describe trends in the epidemiology, care pathways and health outcomes of adult individuals living with type 1 or type 2 diabetes in France from 2010 to 2019. It focused on individuals treated or not with insulin and applied a predictive classification algorithm to accurately distinguish between diabetes types using real-world data.
View Article and Find Full Text PDFAm J Biol Anthropol
September 2025
G. I. Tarha. Departmento de Ciencias Históricas, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain.
Objectives: This study evaluated the influence of genetic diversity, subsistence strategies, age at death, and their interplay on the prevalence of linear enamel hypoplasias (LEHs) in the indigenous populations of the Canary Islands. Additionally, we test the predictive adaptive hypothesis and the plasticity/constraint hypothesis within this unique archeological context.
Methods: LEH incidence, age of occurrence, and the number of stress episodes were assessed macroscopically in a sample of 409 individuals from six of the seven islands comprising the Canarian archipelago during the pre-contact or Indigenous period (2nd-15th century cal CE).
Neurology
September 2025
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL.
Background And Objectives: Cerebral amyloid angiopathy (CAA) is the accumulation of β-amyloid (Aβ) in the walls of small vessels in the leptomeninges and cortex and is a risk factor of intracerebral hemorrhage and dementia, but its underlying mechanism is unknown. We examined cortical proteins in relation to CAA to elucidate the molecular mechanisms underlying CAA.
Methods: Data were collected from participants of 5 community-based cohorts of older adults.
Forensic Sci Int
August 2025
Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL, United States.
The increasing number of forensic cases and solitary deaths ("kodokushi") involving older adults warrants targeted methods to serve this growing and vulnerable group. However, age-at-death estimation past midlife remains challenging due to diminished accuracy of traditional macroscopic age markers, often resulting in a single categorization of older age groups as "50 + ." This study evaluates the utility of cortical bone speed of sound (SoS), measured by quantitative ultrasound (QUS), as an alternative biomarker to quantify age-related changes in cortical bone quality and to estimate age-at-death in older adult skeletons.
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