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Ectopic adipose tissue in subsistence populations with minimal coronary disease, large left atria, and very low rates of atrial fibrillation.
Am J Prev Cardiol
September 2025
Tsimane Health and Life History Project, San Borja, Bolivia.
Background: Greater deposits of epicardial adipose tissue are associated with atrial fibrillation and coronary disease, but have not been studied in subsistence populations.
Methods: We performed CT imaging to measure coronary artery and thoracic aortic calcium (CAC, TAC), epicardial fat thickness (EFT), liver density, and left atrial (LA) anteroposterior diameter and, using a deep learning-enabled software program, epicardial and thoracic fat volume (EFV, TFV), in two remote Amerindian subsistence populations with minimal coronary artery calcification and virtually no atrial fibrillation. We compared 893 adult Tsimane (mean age 58.
Glial cells in the heart: Implications for their roles in health and disease.
J Physiol
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Biomedical and Life Sciences Department, Lancaster University, Lancaster, UK.
Glial cells are essential regulators of brain homeostasis by orchestrating neuronal function, metabolism and immune responses. However, much less is known about peripheral glial cells, particularly those in the heart. This review explores the development, types and functions of cardiac glial cells, including Schwann cells, satellite glial cells and recently identified cardiac nexus glia, with some reference to their central nervous system counterparts.
View Article and Find Full Text PDFEpicardial and pericardial adipose tissue: a plea for standardized definitions and assessment.
Eur Heart J
September 2025
Department of Cardiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO Box 30.001, Groningen 9700 RB, The Netherlands.
Obesity and Atrial Fibrillation: From Mechanisms to Treatment.
Heart Lung Circ
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Centre for Heart Rhythm Disorders, The University of Adelaide, Royal Adelaide Hospital and South Australian Health & Medical Research Institute, Adelaide, SA, Australia. Electronic address:
By 2050, it is projected that 3.8 billion people worldwide will be overweight or obese. Alongside this growing burden of obesity is a parallel rise in the incidence and prevalence of atrial fibrillation (AF).
View Article and Find Full Text PDFFrom Cushion to Culprit: The Role of Epicardial Adipose Tissue in Cardiovascular Disease.
Heart Lung Circ
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Baker Heart and Diabetes Institute, Melbourne, Vic, Australia; Victorian Heart Hospital, Melbourne, Vic, Australia; Victorian Heart Institute, Melbourne, Vic, Australia. Electronic address:
Epicardial adipose tissue (EAT) is the layer of fat located between the visceral pericardium and the myocardium. Emerging research has signified its role in the development of various cardiovascular diseases. The pathogenesis is complex, involving various bioactive compounds that have been implicated in the development of coronary artery disease, heart failure, and arrhythmogenesis.
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