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Laughter is related to better well-being in daily life. Previous cross-sectional research among employees showed a positive relationship between laughter and work-related well-being (i.e., work engagement). However, longitudinal and even bidirectional relationships have not been yet explored. This study thus investigated the longitudinal and reciprocal relationships of laughter, with work engagement and workaholism as positive and negative aspects of work-related well-being. Specifically, we conducted two-wave web-based surveys among Japanese employees via an Internet survey company with a one-year interval, and 855 valid data were analyzed. The hypotheses were then tested using structural equation modeling. The results showed that increases in laughter during the previous year were positively and negatively related to future work engagement and workaholism, respectively. In addition, through changes in laughter, the initial work engagement led to future work engagement (gain cycle), whereas initial workaholism led to future workaholism (loss cycle). These findings suggest that laughter and work-related well-being influence each other reciprocally rather than unidirectionally. This underlines the importance of studying reversed as well as regular causal effects in the relationship between laughter and employee well-being.
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http://dx.doi.org/10.2486/indhealth.2024-0135 | DOI Listing |
Eur J Pharm Biopharm
September 2025
Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy; Department of Women, Child and Public Health Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Unlabelled: The Media-Fill Test is a crucial procedure in the pharmaceutical industry, especially for the production of sterile drugs that do not undergo terminal sterilization (meaning they are prepared directly under aseptic conditions).The primary goal of the Media-Fill Test is to evaluate the overall effectiveness of the aseptic process in preventing microbial contamination. It doesn't serve to test the sterility of an individual production batch, but rather to: Validate the aseptic process, Qualify personnel, Identify critical points and Verify the environment.
View Article and Find Full Text PDFIndian Heart J
September 2025
Department of Medicine, Fortis Hospital, Kangra, India.
Background: An inward force is experienced by the guide catheter during device retrieval resulting in potential risk of deep engagement into the ostio-proximal coronary segment. This undesired movement can result in coronary injury. There is no systematic data or reports of techniques to prevent such inadvertent guide movement during difficult retrieval of devices.
View Article and Find Full Text PDFAm J Pharm Educ
September 2025
School of Pharmacy, University of Washington, Seattle, Washington, USA. Electronic address:
Objectives: To explore experiential education (EE) and preceptor development experts' perceptions of priorities for preceptor development aimed at supporting learner professional identity formation (PIF) and create a framework for preceptor development to inform future preceptor training programs.
Methods: This multi-component study involved: 1) conducting virtual focus groups of EE and preceptor development experts to explore perceived preceptor development needs, including content and learning outcomes, 2) utilizing a modified nominal group technique (NGT) to identify priorities for preceptor development and 3) creating a preceptor development framework for supporting learner PIF. Transcripts were analyzed to identify specific content areas of focus and practical program insights.
Higher education faces growing calls to rethink traditional approaches to teaching, delivery, and assessment, driven by the evolving needs of modern learners. Today's students seek education that is flexible, personalized, and closely aligned with their career goals. Curricular flexibility supports learner-centered education, promotes adaptability, and empowers students by shifting some decision-making from faculty to learners.
View Article and Find Full Text PDFCell Rep Med
August 2025
Department of Biochemistry, Stanford University, Stanford, CA 94305, USA; ChEM-H Institute, Stanford University, Stanford, CA 94305, USA; Arc Institute, Palo Alto, CA 94304, USA. Electronic address:
Only one in five patients respond to immune checkpoint inhibitors, which primarily target adaptive immunity. Ectonucleotide pyrophosphatase/phophodiesterase 1 (ENPP1), the dominant hydrolase of 2'3'-cyclic-GMP-AMP (cGAMP) that suppresses downstream stimulator of interferon genes (STING) signaling, has emerged as a promising innate immunotherapy target. However, existing ENPP1 inhibitors have been optimized for prolonged systemic residence time rather than effective target inhibition within tumors.
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