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With the recent approval of the transcatheter EVOQUE tricuspid valve replacement system to treat severe, symptomatic tricuspid regurgitation, there is a need to define the appropriate patient population and anatomical considerations for this device. In this consensus document, the authors review these considerations, describe the procedural steps and imaging requirements to ensure technical success, and discuss management of complex intraprocedural circumstances.
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http://dx.doi.org/10.1016/j.jcin.2024.07.034 | DOI Listing |
Struct Heart
September 2025
The Carl and Edyth Lindner Research Center at the Christ Hospital, Cincinnati, Ohio, USA.
Severe, untreated tricuspid regurgitation is associated with worse clinical outcomes. While isolated tricuspid valve (TV) surgery has been linked to poor long-term outcomes, transcatheter TV therapies, including edge-to-edge repair and transcatheter tricuspid valve replacement (TTVR), have emerged as effective alternatives and have been shown to improve outcomes, leading to their regulatory approval in the United States. Conduction system abnormalities are commonly seen among patients undergoing TTVR due to the close proximity of the atrioventricular node and the His bundle to the TV annulus.
View Article and Find Full Text PDFInt J Cardiovasc Imaging
September 2025
Department of Cardiology, Bern University Hospital, University of Bern, Bern, Switzerland.
Purpose: A five-grade severity scheme has been introduced for echocardiographic grading of tricuspid regurgitation (TR). Although higher TR grades have been associated with worse prognosis, it is unknown whether they can help determining patient eligibility for transcatheter tricuspid valve interventions (TTVI) and correspond to different anatomical phenotypes. The aim of our study was to investigate the relationship between TR severity and tricuspid valve (TV) anatomy and determine the screening failure rate for TTVI.
View Article and Find Full Text PDFStruct Heart
September 2025
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, Ohio.
•Evaluated ChatGPT-4o and OpenEvidence for structural heart disease decision support.•Among the first to assess the use of artificial intelligence amid rising adoption of TriClip and EVOQUE for transcatheter tricuspid valve interventions.•ChatGPT-4o delivered more accurate responses and proved more clinically reliable.
View Article and Find Full Text PDFEur Heart J
August 2025
Piedmont Heart Institute, Atlanta, Georgia, USA.
Background And Aims: The TRISCEND II trial demonstrated superior clinical benefits for patients with ≥severe tricuspid regurgitation (TR) treated with the EVOQUE transcatheter tricuspid valve replacement (TTVR) system plus medical therapy versus medical therapy alone. This work reports 1-year and 18-month outcomes in patients stratified by baseline TR severity.
Methods: The multicentre, prospective TRISCEND II trial enrolled 400 patients with symptomatic, ≥severe TR and randomised 2:1 to TTVR (n=267) or control (n=133).
Ann Med Surg (Lond)
July 2025
Holy Name Medical Center, Teaneck, New Jersey, USA.
Tricuspid valve disease (TVD), primarily tricuspid regurgitation (TR), is increasingly recognized for its significant morbidity and mortality. Traditional management with medical therapy or high-risk surgical interventions leaves many patients untreated. The emergence of percutaneous interventions introduces a transformative, minimally invasive alternative for high-risk surgical candidates.
View Article and Find Full Text PDF