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http://dx.doi.org/10.1515/cclm-2024-0937 | DOI Listing |
Anal Chem
July 2025
Faculty of Pharmacy, Department of Analytical Chemistry, Ankara University, Ankara 06560, Türkiye.
Bacterial infections significantly impact public health, and the growing threat of antimicrobial resistance underscores the urgent need for rapid and accessible diagnostic tools. This study presents a novel bacteriophage-gated sensor for the selective detection of . The sensor utilizes sulforhodamine B as a fluorescent reporter dye encapsulated in mesoporous silica particles, with bacteriophages acting as gatekeepers.
View Article and Find Full Text PDFJ Biopharm Stat
December 2024
Independent Researcher, Enköping, Sweden.
This article concerns -value-based multiple testing procedures (MTPs) that can be used in a confirmatory clinical study under minimal assumptions in case the requirement for study-success is that at least out of primary/important hypotheses become rejected. Recently, a simple, generally valid Holm-type MTP was discussed that can be used for such a requirement for any from one to . It can only reject at least (or zero) hypotheses, but this increases the power to reject or more hypotheses compared to Holm's step-down MTP.
View Article and Find Full Text PDFFront Chem
November 2024
Guangxi Medical University Cancer Hospital, Nanning, China.
Disposable electrochemical biosensors with high sensitivity are very fit for point-of-care testing in clinical diagnosis. Herein, amino-functionalized, vertically ordered mesoporous silica films (NH-VMSF) attached to an electrochemically polarized screen-printed carbon electrode (p-SPCE) are prepared using a simple electrochemical method and then utilized to construct a gated electrochemical aptasensor for rapid and sensitive determination of carcinoembryonic antigen (CEA). After being treated with the electrochemical polarization procedure, p-SPCE has plentiful oxygen-containing groups and improved catalytic ability, which help promote the stability of NH-VMSF on SPCE without the use of an adhesive layer and simultaneously generate a highly electroactive sensing interface.
View Article and Find Full Text PDFClin Chem Lab Med
February 2025
Department of Laboratory Medicine, CHU UCL Namur Site Godinne, UCLouvain, Yvoir, Belgium.