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http://dx.doi.org/10.23736/S2724-6051.24.06159-7 | DOI Listing |
Introduction: Androgen receptor signaling inhibitors (ARSIs) improve survival in prostate cancer; however, it may increase cardiovascular risks, especially in elderly patients with heart disease.
Case Presentation: A 94-year-old man with aortic valve stenosis, hypertension, and diabetes had a nodal metastatic progression of prostate cancer at 88 years of age, leading to the implementation of androgen deprivation therapy (ADT). After 5 years of therapy, prostate-specific antigen (PSA) re-elevated; however, ADT was maintained.
Cureus
August 2025
Faculty of Health Sciences, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, GRC.
Recurrent dermatofibrosarcoma protuberans (DFSP) of the anterior chest wall in elderly patients presents a complex reconstructive challenge, necessitating approaches that balance oncological radicality with minimized morbidity and optimal tissue quality for potential adjuvant radiotherapy. We report the case of an 84-year-old woman with an eighth recurrence of chest wall DFSP. Following wide local excision with clear margins, a significant soft tissue defect remained.
View Article and Find Full Text PDFIn rectal cancer surgery, maintaining a balance between oncologic control and postoperative quality of life is critical. Sphincter-preserving procedures may offer better functional outcomes, but results vary depending on the technique used. This retrospective, observational, single-center study included 62 patients with adenocarcinoma of the rectum 5 cm from the anal verge, operated between August 2022 and August 2024.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Sublobar resection, including wedge resection (WR) and segmental resection (SR) has been considered for early-stage non-small-cell lung cancer (NSCLC). However, the optimal sublobar approach continues to be a subject of extensive debate within the thoracic surgical community. This study aimed to compare the oncological outcomes of WR and SR in such patients.
View Article and Find Full Text PDFNed Tijdschr Geneeskd
August 2025
Huygens & Versteegh B.V., Zwijndrecht.
In the face of increasing patient demands and the urgent threat of climate change, this article critically examines the current challenges within oncology. The authorsadvocate for a sustainable healthcare system that balances patient care with environmental responsibilities. Highlighting the significant carbon footprint of oncology, driven by costly treatments and pharmaceuticals, the authors argue that the pursuit of aggressive, life-extending therapies often conflicts with goals of accessibility and sustainability.
View Article and Find Full Text PDF