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Objective: To demonstrate the feasibility and efficacy of a new video-observation training method (intensive visual simulation) to improve upper limb function.
Design: Small sample, randomized, evaluator-blind, monocentric study.
Patients: Seventeen early subacute ischaemic stroke patients with complete hemiplegia were randomly assigned to the therapeutic group (n = 8) or control group (CG, n = 9).
Methods: Thirty sessions of intensive visual simulation combined with corrected visual feedback (therapeutic group) or uncorrected visual feedback (control group) were performed over 6 weeks on top of a standard rehabilitation programme.
Main Outcome Measure: 400-point hand assessment test (400p-HA).
Secondary Outcome Measures: Box and Blocks (B&B), Purdue Pegboard test, Minnesota.
Results: The 400p-HA test improved significantly from T0 to 6 months for both groups, with a significant difference between groups at 3 months (MW-UT p = 0.046) and 4 months (MW-UT p = 0.046) in favour of the therapeutic group. One-phase exponential modelling of 400p-HA showed a greater plateau for the therapeutic group (F test p = 0.0021). There was also faster recovery of the ability to perform the B&B tests for the therapeutic group (log-rank test p = 0.03).
Conclusion: This study demonstrated the feasibility and potential efficacy of an intensive visual simulation training programme to improve upper limb function in subacute stroke patients. A larger study is needed to confirm these results.
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http://dx.doi.org/10.2340/jrm.v56.36119 | DOI Listing |
Histol Histopathol
September 2025
Center for Experimental Teaching, School of Pharmacy, Guangzhou Medical University, Guangzhou, China.
Background: The aim of this study was to establish a rat model of premature ovarian failure (POF) with cyclophosphamide (CTX), and explore the molecular basis of POF and the mechanism of Guishen-Erxian Decoction (GSEXD) to improve POF from the perspective of oxidative stress regulation of ovarian granulosa cell (OGC) DNA fragmentation.
Method: The study utilized SD rats to establish a POF model via CTX. Rats were divided into Control, POF group, three GSEXD dosage groups (low, medium, high), and a GSEXD+PI3K agonist group to assess GSEXD's therapeutic effects on oxidative stress, DNA fragmentation and ovarian damage.
Br J Health Psychol
September 2025
Manchester Centre for Health Psychology, School of Health Sciences, University of Manchester, Manchester, UK.
Objective: This study applied the Theoretical Domains Framework (TDF) to explore the barriers and enablers to optimizing post-operative pain management and supporting safe opioid use from the perspectives of both patients and health care professionals, applying the Theoretical Domains Framework (TDF).
Design: Experience-based co-design (EBCD) qualitative study.
Methods: In the initial phase of the EBCD approach, focus groups were conducted comprising 20 participants, including 8 patients and 12 health care professionals involved in post-operative care.
J Med Chem
September 2025
Department of Natural Products and Medicinal Chemistry, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India.
Nitric oxide (NO) is a multifunctional signaling molecule in oncology, influencing tumor progression, apoptosis, and immune responses. In contrast, chlorambucil (Cbl), a DNA-alkylating chemotherapeutic, induces cytotoxicity through DNA damage. Here, we report a photoresponsive nanoparticle platform for sequential codelivery of NO and Cbl, where NO is released within 10 min of irradiation, followed by Cbl release within 30 min.
View Article and Find Full Text PDFPhotochem Photobiol
September 2025
Universidade Estadual Do Oeste Do Paraná (UNIOESTE), Cascavel, Brazil.
The study investigated the impact of different treatments on recovery from calcaneal tendinopathy in rats, focusing on the gastrocnemius muscle. Tendinopathy is caused by repetitive overload, leading to structural collagen damage and chronic muscle inflammation. Three therapeutic approaches were compared: photobiomodulation (PBM), advanced platelet-rich fibrin (A-PRF) injection, and a combination of the two.
View Article and Find Full Text PDFJ Dtsch Dermatol Ges
September 2025
Department of Dermatology, 921 Hospital of Joint Logistics Support Force, The Chinese People's Liberation Army, Changsha, China.
Background: Moderate to severe acne scars pose a therapeutic challenge and often require multimodal treatments. Ablative fractional laser (AFL) and fractional microneedling radiofrequency (FMR) are commonly used, but their alternating application has not been fully studied.
Patients And Methods: In this prospective, randomized, single-blind, split-face trial, 20 patients (Fitzpatrick III-IV) received four treatments at 4-week intervals: one facial side underwent alternating FMR (sessions 1, 3) and AFL (sessions 2, 4), while the contralateral side received AFL alone.