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In this article, we investigate random client selection in the context of horizontal federated learning (FL), whereby only a randomly selected subset of clients transmit their model updates to the server instead of yielding all clients involved. Many researchers have demonstrated that clustering-based client selection constitutes a simple yet efficacious approach to the identification of those clients possessing representative gradient information. Despite the extensive body of research on modified selection methodologies, the majority of prior work is predicated upon the assumption of consistently effective clustering. However, raw gradient-based clustering methods are subject to several challenges: 1) poor effectiveness, the raw high-dimensional gradient of a client is too complex to serve as an appropriate feature for grouping, resulting in large intra-cluster distances and 2) fluctuating effectiveness, due to inherent limitations in clustering, the effectiveness can vary significantly, leading to clusters with diverse levels of heterogeneity. In practice, suboptimal and inconsistent clustering effects can result in clusters with low intra-cluster similarity among clients. The selection of clients from such clusters may impede the overall convergence of training. In this article, we propose FedSTS, a novel client selection scheme to accelerate the FL convergence by variance reduction. The main idea of FedSTS is to stratify a compressed model update in order to ensure an excellent grouping effect, and at the same time reduce the cross-client variance by re-allocating the sample chance among different groups based on their diverse heterogeneity. It strikes this convergence acceleration by paying more attention to those client groups with relatively low similarity and then improving the representativeness of the selected subset as much as possible. Theoretically, we demonstrate the critical improvement of the proposed scheme in variance reduction and present equivalence conditions among different client selection methods. We also present the tighter convergence guarantee of the proposed method thanks to the variance reduction. Experimental results confirm the exceeded efficiency of our approach compared to alternatives.
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http://dx.doi.org/10.1109/TNNLS.2024.3438843 | DOI Listing |
Int J Gynaecol Obstet
September 2025
Department of Gynecology and Obstetrics, Justus Liebig University Giessen, Giessen, Germany.
Even though uterine fibroids are a widespread condition, the range of approved medical treatment options remains limited. In fact, only a few drugs are officially approved for the therapy of fibroids. In both the USA and the European Medicines Agency region, selected gonadotropin-releasing hormone (GnRH) antagonists have been approved for this indication.
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September 2025
Division of Cardiology, Columbia University Irving Medical Center, New York, NY (S.A.P.).
Background: Limited treatment options exist for infrapopliteal disease in patients with chronic limb-threatening ischemia (CLTI), a condition associated with a high risk of limb loss. Interventional management of diseased infrapopliteal vessels with percutaneous transluminal angioplasty (PTA) is associated with high rates of restenosis and reintervention. In the LIFE-BTK trial, the drug-eluting resorbable scaffold (DRS) demonstrated superior 12-month efficacy compared with PTA in a selected CLTI population with predominantly noncomplex, mildly to moderately calcified lesions.
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September 2025
Department of Biomedical Sciences, Humanitas University, Pieve Emanuele-Milan, Italy (F.T., G.A., M.G., K.S., D.D., G.S., M.C.).
Mitral regurgitation is the most common valve disease worldwide. Despite its wide success in inoperable or high-risk surgical patients, transcatheter edge-to-edge repair remains limited by some anatomic features and the not negligible rate of significant residual regurgitation. Transcatheter mitral valve replacement has emerged as a viable alternative that promises to overcome these issues, but its development has been progressing slowly.
View Article and Find Full Text PDFMult Scler
September 2025
Neuroimaging Unit, Neuroimmunology Division, Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Neurology, VA Medical Center, TN Valley Healthcare System, Nashville, TN, USA.
Background: There is limited knowledge on the post-glymphatic structures such as the parasagittal dural (PSD) space and the arachnoid granulations (AGs) in multiple sclerosis (MS).
Objectives: To evaluate differences in volume and macromolecular content of PSD and AG between people with newly diagnosed MS (pwMS), clinically isolated syndrome (pwCIS), or radiologically isolated syndrome (pwRIS) and healthy controls (HCs) and their associations with clinical and radiological disease measures.
Methods: A total of 69 pwMS, pwCIS, pwRIS, and HCs underwent a 3.
Eur J Case Rep Intern Med
September 2025
Department of Internal Medicine, Hospital Universitario San Agustín, Asturias, Spain.
Background: Although splenomegaly is a common finding in Epstein-Barr virus (EBV) infection, splenic infarction is rarely reported and may be under-recognised, especially in adults. Neurological complications such as aseptic meningitis are also uncommon but documented. The simultaneous occurrence of both complications in the context of primary EBV infection is exceptional.
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